Puromycin aminonucleoside

Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.

White crystal

Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.

ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.

An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

[1] SEK C. CHOW  Sten O  Iris Peters. Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis[J]. Experimental cell research, 1995, 216 1: Pages 149-159. DOI:10.1006/excr.1995.1019
[2] Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells
[3] YUKARI EGASHIRA  Hiroo S  Shin Nagaki. Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.[J]. International Journal for Vitamin and Nutrition Research, 2006, 76 1: 28-33. DOI:10.1024/0300-9831.76.1.28
[4] M. HAGIWARA . Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis[J]. Kidney international, 2006, 69 7: Pages 1146-1152. DOI:10.1038/sj.ki.5000207
[5] E K LÖWENBORG  U B B  G Jaremko. Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats.[J]. Nephrology Dialysis Transplantation, 2000, 15 10: 1547-1555. DOI:10.1093/ndt/15.10.1547