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PUROMYCIN DIHYDROCHLORIDE

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PUROMYCIN DIHYDROCHLORIDE Basic information
PUROMYCIN DIHYDROCHLORIDE Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-40
  • Safety Statements 24/25
  • RIDADR 3249
  • WGK Germany 3
  • RTECS AU7355000
  • 3-8-10
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29419090
  • ToxicityLD50 oral in guinea pig: 600mg/kg
MSDS
PUROMYCIN DIHYDROCHLORIDE Usage And Synthesis
  • Chemical Propertieswhite powder
  • UsesPuromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
  • Usesantibacterial
  • UsesPuromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.
  • UsesPuromycin dihydrochloride is a salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.
  • UsesAn aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene.
  • UsesResearch tool for studying protein synthesis; cell line selection agent in gene transfer experiments.
  • General DescriptionWhite powder.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfilePUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. . Behaves as a very weak acid in solution.
  • Fire HazardFlash point data for PUROMYCIN DIHYDROCHLORIDE are not available, but PUROMYCIN DIHYDROCHLORIDE is probably combustible.
  • Purification MethodsPuromycin dihydrochloride is purified by recrystallisation from H2O. The free base, [58-60-6] M 294.3, has m 175.5-177o (172-173o) (from H2O). The sulfate has m 180-187o dec (from H2O), and the picrate monohydrate has m 146-149o (from H2O). [Baker et al. J Am Chem Soc 77 1 1955, Fryth et al. J Am Chem Soc 80 3736 1958.] It is an inhibitor of aminopeptidase and terminates protein synthesis [Reboud et al. Biochemistry 20 5281 1981]. [Beilstein 26 III/IV 3704.]
PUROMYCIN DIHYDROCHLORIDE(58-58-2)Related Product Information
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  • Company Name:Beijing NuoqiYa Biotechnology Co., Ltd. Gold
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