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Succinic anhydride

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Succinic anhydride Basic information
Succinic anhydride Chemical Properties
  • Melting point:118-120 °C(lit.)
  • Boiling point:261 °C(lit.)
  • Density 1,572 g/cm3
  • vapor density 3.5 (vs air)
  • vapor pressure 1 mm Hg ( 92 °C)
  • refractive index 1.4688 (estimate)
  • Flash point:157°C
  • storage temp. Store at 0-5°C
  • solubility 62.9g/l Hydrolysis
  • Specific Gravity1.2340 (20℃)
  • PH2.7 (10g/l, H2O)
  • Water Solubility <0.1 g/100 mL at 21 ºC (decomposes)
  • Sensitive Moisture Sensitive
  • Merck 14,8870
  • BRN 108441
  • Stability:Stable. Incompatible with oxidising agents, strong acids, strong bases, alcohols, amines. Avoid exposure to water or moisture.
  • CAS DataBase Reference108-30-5(CAS DataBase Reference)
  • NIST Chemistry Reference2,5-Furandione, dihydro-(108-30-5)
  • IARC3 (Vol. 15, Sup 7) 1987
  • EPA Substance Registry SystemSuccinic anhydride (108-30-5)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37-22
  • Safety Statements 25-46
  • RIDADR UN 3261 8 / PGII
  • WGK Germany 1
  • RTECS WN0875000
  • 21
  • Autoignition Temperature480 °C
  • TSCA Yes
  • HS Code 29171990
  • Hazardous Substances Data108-30-5(Hazardous Substances Data)
  • ToxicityLD50 orally in Rabbit: 1510 mg/kg
Succinic anhydride Usage And Synthesis
  • DescriptionSuccinic anhydride, also called di hydro - 2,5- furandione , is an organic compound with the molecular formula C4H4O3.This colorless solid is the acid anhydride of succinic acid.
  • Chemical Propertiesfine white crystalline solid
  • UsesIt was used in the preparation of covalently cross-linked oxidized-alginate/N-succinyl-chitosan hydrogels, as injectable systems towards tissue engineering.It was also used in preparing functionalized oxide surfaces on a chip.
  • UsesSuccinic Anhydride is an acidulant that hydrolyzes very slowly to succinic acid in water. it has thermal stability and a low melting point of 118°c which permits it to be used in products at compara- tively low temperatures. it is used as a leavening acidulant for bak- ing powder.
  • ApplicationAlkyl succinic anhydride (ASA) is used as a sizing agent or wet strength additive in paper production.
  • Production MethodsThe compound is produced from succinic anhydride and hydrogen peroxide . This material must be stabilized by using a dehydrating agent such as disodium sulfate or magnesium sulfate.
  • PreparationA solution of succinic acid (500 mg, 42 mmol) and triethylamine (1.23 mL, 42 mmol) in anhydrous THF (120 mL) was allowed to react with triphosgene (42 mg, 7.0 mmol) at ice-water temperature for 10 min. The reaction mixture was subsequently stirred for a further 15 min at room temperature. The solution was then filtered, and the filtrate was concentrated to dryness. The residue was crystallized from ethyl acetate to afford the desired product as white crystals (370 mg, 85%).
  • Synthesis Reference(s)Synthetic Communications, 23, p. 419, 1993 DOI: 10.1080/00397919308009796
  • General DescriptionColorless needles or white crystalline solid. Melting point 237°F. Sublimes at 239°F at 5 mm Hg pressure; and at 198°F and 1 mm Hg pressure. Moderately toxic and an irritant.
  • Air & Water ReactionsReacts slowly with water. Insoluble in water.
  • Reactivity ProfileSuccinic anhydride reacts exothermically with water. Reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
  • Fire HazardFlash point data for Succinic anhydride are not available, however, Succinic anhydride is probably combustible.
  • Safety ProfileExperimental teratogenic effects. Moderately toxic by ingestion. A severe eye irritant. Mutation data reported. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.
  • Purification MethodsCrystallise the anhydride from redistilled acetic anhydride or CHCl3, then filter, wash with diethyl ether and dry it in a vacuum. [Beilstein 17 H 606, 17 V 6.]
Succinic anhydride Preparation Products And Raw materials
Succinic anhydride(108-30-5)Related Product Information
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