2,6-Dichloronicotinonitrile

76175-82-1

40381-90-6

General procedure for the synthesis of 2,6-dichloronicotinonitrile from N-(2,6-dichloropyridin-3-yl)acetamide: To a solution of dichloromethane (100 mL) containing 2,6-dichloro-3-acetamidopyridine (6.3 g, 55% purity) and pyridine (4.93 mL, 61 mmol) was slowly added trifluoroacetic anhydride (4.23 mL, 30 mmol). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under reduced pressure. The crude product was purified by fast chromatography using 85% hexane and 15% ethyl acetate as eluents to give a light yellow product (1.77 g, 90% yield).HPLC analysis showed a retention time of 10.26 min (90% purity) and mass spectrometry analysis showed the molecular ion peak [M+H]+ = 172.9, and the theoretical molecular weight for the molecular formula C6H2Cl2N2 was 171.9 g/mol.