酮咯酸氨丁三醇
酮咯酸氨丁三醇 性质
| 熔点 | 160-161 C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O: 15 mg/mL ，−20 °C 下至少稳定一个月，可溶 |
| 形态 | 结晶 |
| 颜色 | 白色至浅黄色至浅橙色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | H2O: soluble 15mg/mL, clear, colorless to faintly yellow (stable at least one month at -20 °C.) |
| 最大波长(λmax) | 322nm(MeOH)(lit.) |
| Merck | 14,5306 |
| 稳定性 | 吸湿性 |
| InChI | InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2 |
| InChIKey | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
| SMILES | C(N)(CO)(CO)CO.C(C1C=CC=CC=1)(C1=CC=C2C(C(=O)O)CCN12)=O |
| CAS 数据库 | 74103-07-4(CAS DataBase Reference) |
酮咯酸氨丁三醇 用途与合成方法
| Target | Value |
|
COX1
() | 20 nM |
|
COX2
() | 20 nM |
Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2.
Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 25-36/37/38-23/24/25 |
| 安全说明 | 26-45-36/37/39 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | UY7759900 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 海关编码 | 2933995500 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 急性毒性 类别3经口 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
酮咯酸氨丁三醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | S5698 | 酮咯酸氨丁三醇 | 74103-07-4 | 25mg | 794.85 |
| 2026-03-03 | S5698 | 酮咯酸氨丁三醇 | 74103-07-4 | 10mM (1mL in DMSO) | 810.81 |
