供应商 相关产品 基本信息 物理化学性质 安全数据 常见问题列表 知名试剂公司产品信息 酮咯酸氨丁三醇价格(试剂级)
网站主页 > Cas数据库列表 > 74103-07-4

74103-07-4

供应商 相关产品 基本信息 物理化学性质 安全数据 常见问题列表 知名试剂公司产品信息 酮咯酸氨丁三醇价格(试剂级)

产品图片

基本信息

中文
酮咯酸氨丁三醇
英文名称
(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID, TRIS (HYDROXYMETHYL) AMINOMETHANE SALT
(+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt
(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID TRIS SALT
KETOROLAC TRIS SALT
KETOROLAC TROMETHAMINE
KETOROLAC TROMETHAMINE SALT
KETROLAC TROMETHAMINE SALT
TORADOL
TORADOL TRIS SALT
3-dihydro-5-benzoyl-(+-)-compd.with2-1h-pyrrolizine-1-carboxylicaci
amino-2-(hydroxymethyl)-1,3-propanediol(1:1)
syntex
KEROROLACTROMETHAMINE
KETOROLACTROMETHAMINE,USP
(+/-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt
Toradol, (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt
CAS
74103-07-4
中文名称
(+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸氨丁三醇盐
酮咯酸氨丁三醇
辛太克斯(浮选剂)
(+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸氨丁三醇盐
分子式
C19H24N2O6
MDL 编号
MFCD00887595
分子量
376.4
MOL 文件
74103-07-4.mol

物理化学性质

溶解度 
H2O: 15 mg/mL stable at least one month at −20 °C., soluble

form 
crystalline

安全数据

危险品标志 
T
危险类别码 
R25-R36/37/38
安全说明 
S26-S45
危险品运输编号 
UN 2811 6.1/PG 3

WGK Germany 
3

RTECS 
UY7759900

危险等级
6.1(a)
包装类别
II
海关编码
2933995500

常见问题列表

概述
酮咯酸氨丁三醇是醇类有机物,其生物活性与左旋S(-)有关,可抑制前列腺素生物合成。
用途
咯酸氨丁三醇为吡咯烷羧酸衍生物,是由左旋(-)和右旋(+)异构体组成的消旋体,其右旋S(+)异构体具有止痛作用。
生物活性
Ketorolac tromethamine是一种合成的吡呤环羧酸衍生物,具有消炎、止痛和退热活性。它是非选择性的COX抑制剂,对COX-1和COX-2的IC50值都是20 nM。
靶点
TargetValue
COX1
()
20 nM
COX2
()
20 nM

体外研究

Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2.


体内研究

Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group.


知名试剂公司产品信息

酮咯酸氨丁三醇价格(试剂级)

酮咯酸氨丁三醇价格(试剂级)
更新日期产品编号产品名称包装价格
2021/01/25K0053酮咯酸氨丁三醇
Ketorolac Tromethamine
1g390元
2021/01/25K0053酮咯酸氨丁三醇
Ketorolac Tromethamine
5g1490元

供应商信息更多