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Benoxinate Hydrochloride

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Benoxinate Hydrochloride Basic information
Benoxinate Hydrochloride Chemical Properties
  • Melting point:157-160 C
  • solubility Very soluble in water, freely soluble in ethanol (96 per cent).
  • form neat
  • Merck 13,1045
  • CAS DataBase Reference5987-82-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-20/21/22
  • Safety Statements 22-26-36
  • RIDADR UN 1544PSN2 6.1 / PGIII
  • WGK Germany 3
  • RTECS DG1502900
  • HS Code 29225000
  • ToxicityLD50 scu-rat: 60 mg/kg NIIRDN 6,154,82
Benoxinate Hydrochloride Usage And Synthesis
  • Chemical PropertiesWhite or almost white, crystalline powder or colourless crystals.
  • Usesantibacterial, coccidiostat
  • UsesBenoxinate Hydrochloride is a local anesthetic used in ophthalmology to numb the surface of the eye for a variety of procedures.
  • Usesanticonvulsant
  • DefinitionChEBI: The monohydrochloride salt of oxybuprocaine.
  • brand nameDorsacaine (Novartis).
  • Safety ProfilePoison by subcutaneous route. A topical anesthetic. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • structure and hydrogen bondingOxybuprocaine hydrochloride acts as a local anesthetic and is used in eye drop formulations. Mod. II, the stable polymorphic form, contains two molecules with markedly different conformations (stretched and bent). The 13C CPMAS NMR spectrum of this sample12 showed crystallographic splittings arising from the fact that there are two molecules in the asymmetric unit. An INADEQUATE two-dimensional experiment was used to link signals for the same independent molecule. Of the four ethyl groups attached to NHt nitrogens, one gives rise to unusually low chemical shifts, very different from those of the other three groups. This was attributed to gamma-gauche conformational effects, and confirmed by shielding computations. The oxybuprocaine system is too large for computations performed on the crystallographic unit and the intermolecular shielding effects have to be neglected. Nevertheless, the computed shifts do match the order of the experimental ones. The assignment of 13C signals to specific carbons in the two crystallographically inequivalent molecules of oxybuprocaine polymorph showed the power of NMR crystallography.
Benoxinate Hydrochloride Preparation Products And Raw materials
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Benoxinate HydrochlorideSupplierMore
  • Company Name:Wuhan Runzeweiye Technology Co., Ltd. Gold
  • Tel:15172337137
  • Company Name:Shandong Haiyou Furuida Pharmaceutical Co., Ltd. Gold
  • Tel:15315392673 0539-6376513
  • Company Name:Ningbo Disheng Chemical Co., Ltd. Gold
  • Tel:0574-27862498
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-