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Saccharin sodium dihydrate
Saccharin sodium dihydrate Chemical Properties
- Melting point:> 300℃
- Flash point:>200°C
- storage temp. 2-8°C
- solubility 1000g/l
- PH6.0-7.5 (100g/l, H2O, 20℃)
- Water Solubility Soluble in water. Slightly soluble in alcohol
- Merck 14,8311
- CAS DataBase Reference6155-57-3(CAS DataBase Reference)
Saccharin sodium dihydrate Usage And Synthesis
- DescriptionSaccharin sodium dihydrate is the sodium dihydrate form of saccharin, which belongs to the family of aromatic homomonocyclic compounds. It is an artificial sweetener that is hundreds times as sweet as sucrose. It is mainly used as a food additive to sweeten many products such as drinks, candies, cookies, and medicine. Saccharin is relatively safe for human beings without providing food energy and any nutritional value. It is also safe for diabetes patients to consume.
- Chemical Propertiesdihydrate granular
- Chemical PropertiesSaccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.
- UsesSweetener (non-nutritive).
- Production MethodsSaccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.
- brand nameSucaryl (Ross).
- Pharmaceutical ApplicationsSaccharin sodium is an intense sweetening agent used in beverages,
food products, table-top sweeteners, and pharmaceutical formulations
such as tablets, powders, medicated confectionery, gels,
suspensions, liquids, and mouthwashes. It is also used
in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.
- SafetyThere has been considerable controversy concerning the safety of
saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg
- storageSaccharin sodium is stable under the normal range of conditions
employed in formulations. Only when it is exposed to a high
temperature (125℃) at a low pH (pH 2) for over 1 hour does
significant decomposition occur. The 84% grade is the most stable
form of saccharin sodium since the 76% form will dry further under
ambient conditions. Solutions for injection can be sterilized by
Saccharin sodium should be stored in a well-closed container in a dry place.
- IncompatibilitiesSaccharin sodium does not undergo Maillard browning.
- Regulatory StatusAccepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Saccharin sodium dihydrate Preparation Products And Raw materials
- Saccharin Sodium N-cyclohexylsulfamate Saccharin sodium Sodium acetate Sodium hydroxide 1,2-Benzisothiazol-3(2H)-one SACCHARIN SODIUM SALT DIHYDRATE Phenylmethylsulfonyl fluoride Sodium bicarbonate Diclofenac sodium Trisodium phosphate O-Phthalimide Sodium benzoate Phthalhydrazide FOROXYMITHINE sodium 2-Nitrobenzenesulfonyl chloride Saccharin sodium dihydrate
Saccharin sodium dihydrateSupplierMore
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