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Phenylmethylsulfonyl fluoride

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Phenylmethylsulfonyl fluoride Basic information
Phenylmethylsulfonyl fluoride Chemical Properties
  • Melting point:92-95 °C
  • Boiling point:112 °C16 mm Hg(lit.)
  • Density 0.797 g/mL at 20 °C
  • Flash point:222 °F
  • storage temp. 2-8°C
  • solubility dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C.
  • form Needles (May Agglomerate)
  • color White
  • Water Solubility hydrolysis
  • Sensitive Moisture Sensitive
  • Merck 14,7542
  • BRN 2088311
  • InChIKeyYBYRMVIVWMBXKQ-UHFFFAOYSA-N
  • CAS DataBase Reference329-98-6(CAS DataBase Reference)
  • EPA Substance Registry SystemBenzenemethanesulfonyl fluoride (329-98-6)
Safety Information
  • Hazard Codes F,T,C
  • Risk Statements 11-34-25-23/24/25
  • Safety Statements 7-16-45-36/37/39-28A-26-27
  • RIDADR UN 3261 8/PG 2
  • WGK Germany 3
  • RTECS XT8050000
  • 3-10-21
  • Hazard Note Highly Toxic/Corrosive
  • TSCA T
  • HazardClass 8
  • PackingGroup III
  • HS Code 29241990
  • ToxicityLD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky)
MSDS
Phenylmethylsulfonyl fluoride Usage And Synthesis
  • Chemical PropertiesWhite to cream solid
  • UsesPMSF is an irreversible serine/cysteine protease inhibitor
  • UsesPhenylmethylsulfonyl fluoride is used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase.
  • UsesStandard protease inhibitor in biological research; in protein purification to prevent proteolytic degradation.
  • DefinitionChEBI: An acyl fluoride with phenylmethanesulfonyl as the acyl group.
  • Purification MethodsPurify PMSF by recrystallisation from *C6H6, pet ether or CHCl3/pet ether. [Davies & Dick J Chem Soc 483 1932, cf Tullock & Coffman J Org Chem 23 2016 1960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney & Gould J Am Chem Soc 85 997 1963]. [Beilstein 11 III 331.]
Phenylmethylsulfonyl fluoride(329-98-6)Related Product Information
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