Basic information Uses Mechanisms of action Clinical Application Safety Related Supplier
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Diclofenac sodium

Basic information Uses Mechanisms of action Clinical Application Safety Related Supplier
Diclofenac sodium Basic information
Diclofenac sodium Chemical Properties
  • Melting point:288-290°C
  • Density 0.781 g/cm3
  • storage temp. -20°C Freezer
  • solubility H2O: 50 mg/mL
  • pka4(at 25℃)
  • form White solid
  • Water Solubility Soluble in water to 50mg/ml.
  • Merck 14,3081
  • Stability:Stable.
  • InChIKeyKPHWPUGNDIVLNH-UHFFFAOYSA-M
  • CAS DataBase Reference15307-79-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes T,Xi
  • Risk Statements 25-36/37/38-63
  • Safety Statements 22-36/37-45-36-26-60-20
  • RIDADR UN 2811 6.1/PG 3
  • WGK Germany 3
  • RTECS AG6330000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29224999
  • ToxicityLD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)
MSDS
Diclofenac sodium Usage And Synthesis
  • Uses

    Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.

  • Mechanisms of action

    Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.

  • Clinical Application

    Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.

  • Chemical PropertiesOff-White Crystalline Solid
  • UsesA nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
  • UsesA nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
  • UsesAn inhibitor of Cox-1 and Cox-2.
  • DefinitionChEBI: The sodium salt of diclofenac.
  • brand nameSolaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.
  • World Health Organization (WHO)The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
  • Clinical UseDiclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
  • Veterinary Drugs and TreatmentsThe equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.
Diclofenac sodium Preparation Products And Raw materials
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