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Diclofenac sodium

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Diclofenac sodium Basic information
Diclofenac sodium Chemical Properties
  • Melting point:288-290°C
  • storage temp. -20°C Freezer
  • solubility H2O: 50 mg/mL
  • pka4(at 25℃)
  • form White solid
  • Water Solubility Soluble in water to 50mg/ml.
  • Merck 14,3081
  • Stability:Stable.
  • InChIKeyKPHWPUGNDIVLNH-UHFFFAOYSA-M
  • CAS DataBase Reference15307-79-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes T,Xi
  • Risk Statements 25-36/37/38-63
  • Safety Statements 22-36/37-45-36-26-60-20
  • RIDADR UN 2811 6.1/PG 3
  • WGK Germany 3
  • RTECS AG6330000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29224999
  • ToxicityLD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)
MSDS
Diclofenac sodium Usage And Synthesis
  • Chemical PropertiesOff-White Crystalline Solid
  • UsesA nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
  • UsesA nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
  • UsesAn inhibitor of Cox-1 and Cox-2.
  • DefinitionChEBI: The sodium salt of diclofenac.
  • brand nameSolaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.
  • World Health Organization (WHO)The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
  • Veterinary Drugs and TreatmentsThe equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.
Diclofenac sodium Preparation Products And Raw materials
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