5-Amino-2,3-dichloropyridine

22353-40-8

7439-89-6

98121-41-6

Example 10 Synthesis of 5-amino-2,3-dichloropyridine: 77.2 g (0.4 mol) of 2,3-dichloro-5-nitropyridine was dissolved in 135 mL of glacial acetic acid and 800 mL of water was slowly added under stirring conditions. Subsequently, 111.7 g (2 mol) of iron powder was added in batches, and the reaction temperature was controlled not to exceed 50 °C. After completion of the reaction, the mixture was filtered and the filtrate was extracted using ethyl acetate. The extracted organic phase was washed with water to neutral and subsequently dried with anhydrous magnesium sulfate and concentrated by rotary evaporator. The final product was purified by recrystallization from toluene to obtain 85% yield with a melting point of 107 °C.