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2-Aminopyridine

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2-Aminopyridine Basic information
2-Aminopyridine Chemical Properties
  • Melting point:59 °C
  • Boiling point:204-210 °C(lit.)
  • Density 1.0308 (estimate)
  • vapor pressure 5 hPa (125 °C)
  • refractive index 1.5560 (estimate)
  • Flash point:198 °F
  • storage temp. Refrigerator, Under Inert Atmosphere
  • solubility 890g/l
  • pka6.82(at 20℃)
  • form Crystalline Powder, Crystals or Flakes
  • color Cream to light yellow-beige
  • OdorCharacteristic odour
  • Water Solubility Slightly soluble. 1-5 g/100 mL at 19 ºC
  • Sensitive Hygroscopic
  • Merck 14,473
  • BRN 105785
  • Exposure limitsNIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 5 ppm; OSHA PEL: 0.5 ppm; ACGIH TLV: TWA 0.5 ppm.
  • CAS DataBase Reference504-29-0(CAS DataBase Reference)
  • NIST Chemistry Reference2-Pyridinamine(504-29-0)
  • EPA Substance Registry System2-Aminopyridine (504-29-0)
Safety Information
MSDS
2-Aminopyridine Usage And Synthesis
  • Chemical Propertiescream to light yellow-beige crystalline powder,
  • Chemical Properties2-Aminopyridine is a flammable, colorless crystalline solid, or white leaflets or powder, or colorless liquid with a characteristic odor
  • Physical propertiesColorless to yellow crystals, leaflets, flakes, or powder with a characteristic odor. May darken after prolonged storage.
  • UsesUsed to label neutral and acidic glycans for fluorescent and UV detection in HPLC.1 2-AP has also been used to derivatize sialyloligosaccharides for detection in FAB-MS.2
  • UsesCompound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes
  • UsesThe main use of 2-aminopyridine is in manufacturing pharmaceuticals such as antihistamines.
  • Synthesis Reference(s)The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
    Tetrahedron Letters, 11, p. 3901, 1970
  • General DescriptionWhite powder or crystals or light brown solid.
  • Air & Water ReactionsDecomposes in air. Soluble in water.
  • Reactivity Profile2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .
  • HazardToxic.
  • Health Hazard2-Aminopyridine causes central nervous system effects.
  • Fire Hazard2-Aminopyridine is combustible.
  • Safety ProfilePoison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Toxic effects resemble strychnine poisoning. Human systemic effects by inhalation: somnolence, convulsions, and antipsychotic effects. Human central nervous system effects by inhalation. When heated to decomposition it emits highly toxic fumes of NOx,.
  • Potential Exposure2-Aminopyridine is used in the manufacture of pharmaceuticals; especially antihistamines.
  • CarcinogenicityThe LD50 in mice by intraperitoneal injection was 35 mg/kg; lethal doses in animals also produced excitement, tremors, convulsions and tetany.1 Fatal doses were readily absorbed through the skin. A 0.2 M aqueous solution dropped in a rabbit’s eye was only mildly irritating.
    2-Aminopyridine was not mutagenic in a variety of Salmonella tester strains with or without metabolic activation.
  • Environmental FateSoil. When radio-labeled 4-aminopyridine was incubated in moist soils (50%) under aerobic conditions at 30 °C, the amount of 14CO2 released from an acidic loam (pH 4.1) and an alkaline, loamy sand (pH 7.8) was 0.4 and 50%, respectively (Starr and Cunningham, 1975).
    Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
  • ShippingUN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • Purification MethodsIt crystallises from *benzene/pet ether (b 40-60o) or CHCl3 /pet ether. [Beilstein 22/8 V 280.]
  • IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides
  • Waste DisposalIncineration with nitrogen oxides removal from effluent gas.
2-Aminopyridine Preparation Products And Raw materials
2-Aminopyridine(504-29-0)Related Product Information
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