Diclofenac Sodium Salt

Diclofenac sodium salt is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity.

Diclofenac sodium salt, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. It is often used in combination with misoprostol to prevent NSAID-induced gastric ulcers.

Acylation of N-phenyl-2,6- dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2,6- dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.