Description Reference
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(+)-Pilocarpine hydrochloride

Description Reference
(+)-Pilocarpine hydrochloride Structure
(+)-Pilocarpine hydrochloride
  • CAS No.54-71-7
  • Chemical Name:(+)-Pilocarpine hydrochloride
  • CBNumber:CB1236112
  • Molecular Formula:C11H17ClN2O2
  • Formula Weight:244.72
  • MOL File:54-71-7.mol
(+)-Pilocarpine hydrochloride Property
  • Melting point: :202-205 °C(lit.)
  • alpha  :89 º (C=5, H2O)
  • storage temp.  :2-8°C
  • solubility  :H2O: 100 mg/mL
  • form  :powder
  • color  :white
  • Water Solubility  :soluble
  • Sensitive  :Hygroscopic
  • Merck  :14,7424
  • BRN  :4034491
  • Stability: :Hygroscopic
  • CAS DataBase Reference :54-71-7(CAS DataBase Reference)
  • FDA UNII :0WW6D218XJ
  • EPA Substance Registry System :Pilocarpine monohydrochloride (54-71-7)
Safety
  • Hazard Codes  :T+,T
  • Risk Statements  :26/28-25-23
  • Safety Statements  :25-45
  • RIDADR  :UN 1544 6.1/PG 3
  • WGK Germany  :3
  • RTECS  :TK1450000
  • F  :3-8-10
  • HazardClass  :6.1
  • PackingGroup  :III
  • HS Code  :29399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H330
  • Precautionary statements P260-P284-P301+P310+P330-P304+P340+P310-P403+P233
(+)-Pilocarpine hydrochloride Price More Price(13)
  • Brand: Sigma-Aldrich
  • Product number: P0472
  • Product name : Pilocarpine hydrochloride
  • Purity: meets USP testing specifications
  • Packaging: 10g
  • Price: $344
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1538902
  • Product name : Pilocarpine hydrochloride
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $352.8
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14487
  • Product name : (+)-Pilocarpine (hydrochloride)
  • Purity: ≥98%
  • Packaging: 5g
  • Price: $150
  • Updated: 2018/11/13
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14487
  • Product name : (+)-Pilocarpine (hydrochloride)
  • Purity: ≥98%
  • Packaging: 1g
  • Price: $33
  • Updated: 2018/11/13
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: PHR1493
  • Product name : Pilocarpine hydrochloride
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 500mg
  • Price: $81
  • Updated: 2019/12/02
  • Buy: Buy

(+)-Pilocarpine hydrochloride Chemical Properties,Usage,Production

  • Description It is a bioactive chemical usually used as pharmaceutical agents such as acetylcholine receptor agonist, antiglaucoma agent, moitic, and sialogogue. Specifically, due to its desirable activity as acetylcholine receptor agonist, this chemical has been introduced to regulate muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.1 Moreover, because of its good antiglaucoma effect, this substance is applied in a timolol plus maximum-tolerated antiglaucoma therapy.2 In addition, this chemical has been demonstrated to show a favourable miotic activity when incorporated into polymer capsules.3 Besides, this compound can be utilized to relieve the xerostomia due to chronic graft-versus-host disease or total-body irradiation after bone-marrow transplantation for hematologic malignancies.4
  • Reference
    1. Li, B.; Duysen, E. G.; Volpicelli-Daley, L. A.; Levey, A. I.; Lockridge, O., Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacol. Biochem. Behav. 2003, 74, 977-986.
    2. Zimmerman, T. J.; Gillespie, J. E.; Kass, M. A.; Yablonski, M. E.; Becker, B., TIMOLOL PLUS MAXIMUM-TOLERATED ANTI-GLAUCOMA THERAPY. Arch. Ophthalmol. 1979, 97, 278-279.
    3. V Vidmar; S Pepeljnjak; Jalsenjak, I., The in vivo evaluation of poly(lactic acid) microcapsules of pilocarpine hydrochloride. Journal of Microencapsulation 1985, 2, 289-292.
    4. Nagler, R. M.; Nagler, A., Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. Bone Marrow Transplant. 1999, 23, 1007-1011.
  • Chemical Properties Crystalline Solid
  • Uses Acetylcholine receptor agonist
  • Uses (+)-Pilocarpine hydrochloride is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.
  • Uses Antiglaucoma agent; miotic; sialogogue.
  • brand name Pilopine (Alcon); Salagen (Millot Laboratories, France).
  • General Description Pilocarpine monohydrochlorideis the hydrochloride of an alkaloid obtainedfrom the dried leaflets of Pilocarpus jaborandi or P. microphyllus,in which it occurs to the extent of about 0.5% togetherwith other alkaloids.
  • Biological Activity Muscarinic agonist.
  • Safety Profile Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects: cardiac changes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PILOCARPINE.
  • Veterinary Drugs and Treatments Pilocarpine is a miotic agent that is rarely used in the treatment of canine primary glaucoma. Pilocarpine causes the ciliary body muscle to constrict placing posteriorly directed tension on the base of the iris to mechanically pull open the iridocorneal angle structures. By causing miosis, it may prevent closure of the iridocorneal angle by preventing excess iris tissue from peripherally compromising the outflow of aqueous humor. Pilocarpine has also been used for diagnostic localization of parasympathetic denervation of the iris sphincter caused by lesions or trauma to Cranial Nerve III.
    The popularity of treatment of KCS with ophthalmic cyclosporine and tacrolimus has been associated with a decline in the use of pilocarpine for this disease; however, pilocarpine is still used orally as the primary treatment of neurogenic keratoconjunctivitis sicca in dogs as this condition does not respond to cyclosporine or tacrolimus.
(+)-Pilocarpine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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  • Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
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