Chemical Properties
White to off-white crystalline powder
Uses
Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Hazard
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Targets the central nervous system, liver, kidneys, and heart. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.
Safety Profile
Moderately toxic by subcutaneousroute. When heated to decomposition it emits toxicvapors of NOx, HCl, and Clí.
Solubility in organics
Soluble in ethanol, chloroform, and alcohol. Insoluble in ether.
Purification Methods
Purify it like the bromide above. [Beilstein 4 IV 327.]
References
[1] C Spagnuolo. “Gel filtration and reactivity of sulphydryl groups of human hemoglobin in concentrated triethylamine hydrochloride solutions.” The Italian journal of biochemistry 21 4 (1972): 221–9.
[2] G. Tian, Qi-Li Yuan, Huanhuan Du. “The Effects of Benzene on the Structure and Properties of Triethylamine Hydrochloride/Chloroaluminate.” Crystals 6 1 (2021).
[3] Zhe Zhang. “Solubility Determination and Model Evaluation of Triethylamine Hydrochloride in Three Binary Mixed Solvents.” Journal of Solution Chemistry 53 10 (2024): 1353–1373.
[4] Junfeng Teng . “Measurement, correlation, and analysis of the solubility of triethylamine hydrochloride in ten pure solvents.” Journal of Molecular Liquids 390 (2023): Article 123040.
