Butanon

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H319：Verursacht schwere Augenreizung.

  H336：Kann Schläfrigkeit und Benommenheit verursachen.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Butanone Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

• CHEMISCHE GEFAHREN

  Reagiert sehr heftig mit starken Oxidationsmitteln und anorganischen Säuren unter Feuer- und Explosionsgefahr. Greift einige Kunststoffe an.

• ARBEITSPLATZGRENZWERTE

  TLV: 200 ppm (als TWA) 300 ppm (als STEL); BEI vorhanden; (ACGIH 2005).
  MAK: 200 ppm 600 mg/m? Spitzenbegrenzung: überschreitungsfaktor I(1); Hautresorption; Schwangerschaft: Gruppe C; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen und die Atemwege. Möglich sind Auswirkungen auf das Zentralnervensystem. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zu Bewusstlosigkeit führen.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Die Flüssigkeit entfettet die Haut. Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.

• LECKAGE

  Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Kanalisation spülen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R36:Reizt die Augen.
  R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S9:Behälter an einem gut gelüfteten Ort aufbewahren.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

• Aussehen Eigenschaften

  C4H8O; Methylethylketon, Ethylmethylketon, MEK. Farblose Flüssigkeit, die nach Lösemitteln riecht.

• Gefahren für Mensch und Umwelt

  Reizt die Augen und die Atmungsorgane.
  Nicht mit Oxidationsmitteln, Chloroform oder Alkalihydroxiden in Kontakt bringen. Gefährliche Zersetzungsprodukte sind Peroxide. Leichtentzündlich.
  LD₅₀ (oral, Ratte): 2737 mg/kg.

• Schutzmaßnahmen und Verhaltensregeln

  Schutzhandschuhe als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Dämpfe nicht einatmen.
  Mit flüssigkeitsbindendem Material, z. B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
  Wasser, Pulver, Schaum.
  Brennbar. Dämpfe schwerer als Luft. Mit Luft Bildung explosionsfähiger Gemische möglich. Im Brandfall Entstehung gefährlicher Brandgase möglich.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser abwaschen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Augenarzt hinzuziehen.
  Nach Einatmen: Frischluft.
  Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung sofort ablegen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als halogenfreie, organische Lösemittelabfälle.

• Beschreibung

  2-Butanone is a stable, highly flammable chemical. It is incompatible with oxidising agents, bases, and strong reducing agents. It is a colourless liquid with a sharp, sweet odour. 2-Butanone is produced in large quantities. It is used as a solvent and nearly half of its use is in paints and other coatings because it will quickly evaporate into the air and it dissolves many substances. It is also used in glues and as a cleaning agent.

• Chemische Eigenschaften

  Methyl ethyl ketone (MEK) is a colorless liquid with an odor that has been described as moderately sharp, fragrant, peppermint, or acetone like. It soluble in water up to 28% by weight and is miscible with many other organic solvents. The lower explosive limit is 1.4% and the upper explosive limit is 11.4%. Methyl ethyl ketone may be incompatible with strong oxidizers, amines, ammonia, inorganic acids, caustics, isocyanates, and pyridines. When used industrially, methyl ethyl ketone must be handled with caution, as it is a Class lB flammable liquid NIOSH (2010).

• Physikalische Eigenschaften

  2-Butanone is a clear, colorless, volatile, very flammable liquid with a sweet, mint or acetone-like odor. Odor threshold concentration is 10.0 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 5.8 mg/m3 (2.0 ppmv) and 16 mg/m3 (5.4 ppmv), respectively (Hellman and Small, 1974). It is incompatible with oxidizing agents, bases, and strong reducing agents. It is a colorless liquid with a sharp, sweet odor. 2-Butanone is produced in large quantities. It is used as a solvent and nearly half of its use is in paints and other coatings because it quickly evaporates into the air and it dissolves many substances. It is also used in glues and as a cleaning agent.

• Occurrence

  Reported found as an impurity among products from the dry distillation of wood and in the oil (extracted with ether) of black tea; it is also present in coffee, cheese, bread, some citrus oils and some other natural products (grape, raspberry).

• Verwenden

  MEK is used as a solvent for various coating systems, for example, vinyl, adhesives, nitrocellulose, and acrylic coatings. It is used in paint removers, lacquers, varnishes, spray paints, sealers, glues, magnetic tapes, printing inks, resins, rosins, cleaning solutions, and for polymerization. It is found in other consumer products, for example, household and hobby cements, and wood-filling products. MEK is used in dewaxing lubricating oils, the degreasing of metals, in the production of synthetic leathers, transparent paper and aluminum foil, and as a chemical intermediate and catalyst. It is an extraction solvent in the processing of foodstuffs and food ingredients. MEK can also be used to sterilize surgical and dental equipment.
  In addition to its manufacture, environmental sources of MEK include exhaust from jet and internal combustion engines, and industrial activities such as gasification of coal. It is found in substantial amounts in tobacco smoke. MEK is produced biologically and has been identified as a product of microbial metabolism. It has also been found in plants, insect pheromones, and animal tissues, and MEK is probably a minor product of normal mammalian metabolism. It is stable under ordinary conditions but can form peroxides on prolonged storage; these may be explosive.

• Verwenden

  Methyl ethyl ketone (2-butanone, ethyl methyl ketone, methyl acetone) is an organic solvent of relatively low toxicity, which is found in many applications. It is used in industrial and commercial products as a solvent for adhesives, paints, and cleaning agents and as a de-waxing solvent. A natural component of some foods, methyl ethyl ketone can be released into the environment by volcanoes and forest fires.It is used in themanufacture of smokeless powder and colorless synthetic resins, as a solvent, and insurface coating. It is also used as a flavoringsubstance in food.

• Verwenden

  2-Butanone is an eye irritant that has been used as a water soluble photoinitiator for the photopolymerization of methacrylic acid (MAA). As solvent; in the surface coating industry; manufacture of smokeless powder; colorless synthetic resins.

• Definition

  ChEBI: A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2.

• Definition

  A colorless volatile liquid ketone. It is manufactured by the oxidation of butane and used as a solvent.

• synthetische

  By catalytic dehydrogenation of secondary butyl alcohol; by dehydration of butane-2,3-diol by refluxing with 25% aqueous H2SO4. Industrially, it is also prepared by controlled oxidation of butane, by dry distillation of calcium acetate and calcium propionate, or by refluxing methyl acetoacetate and diluted H2SO4.

• Vorbereitung Methode

  Methyl ethyl ketone is commercially manufactured from nbutene in a metal-catalyzed hydrogenation reaction that proceeds through the intermediate formation of 2-butanol . A second method of synthesis involves the liquid- phase oxidation of n-butane with the formation of acetic acid as a coproduct.

• Taste threshold values

  Taste characteristics at 5 ppm: chemical-like and slightly fruity green.

• Allgemeine Beschreibung

  Methyl ethyl ketone (MEK) is a colourless liquid with a sweet and sharp odour. It is soluble in alcohol, ether, acetone benzene, and water. It is a solvent often found in mixtures with acetone, ethyl acetate, n-hexane, toluene, or alcohols. It has applications in the surface coating industry and in the de-waxing of lubricating oils. MEK is used in the manufacture of colourless synthetic resins, artificial leather, rubbers, lacquers, varnishes, and glues.

• Air & Water Reaktionen

  Highly flammable. Slightly soluble in water.

• Reaktivität anzeigen

  Amines are chemical bases. They neutralize acids to form salts plus water.These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

• Hazard

  Flammable, dangerous fire risk. Toxic by ingestion.

• Health Hazard

  Occupational workers are exposed to 2-butanone by breathing contaminated air in workplaces associated with the production or use of paints, glues, coatings, or cleaning agents. Prolonged exposures to 2-butanone cause symptoms of poisoning such as cough, dizziness, drowsiness, headache, nausea, vomiting, dermatitis, irritation of the nose, throat, skin, and eyes and at very high levels cause drooping eyelids, uncoordinated muscle movements, loss of consciousness, and birth defects. Chronic inhalation studies in animals have reported slight neurological, liver, kidney, and respiratory effects. However, information on the chronic (long-term) effects of 2-butanone (methyl ethyl ketone) in humans is limited.

• Health Hazard

  The acute toxicity of methyl ethyl ketone is low. Exposure to high concentrations can cause headache, dizziness, drowsiness, vomiting, and numbness of the extremities. Irritation of the eyes, nose, and throat can also occur. Methyl ethyl ketone is considered to have adequate warning properties.
  Repeated or prolonged skin exposure to methyl ethyl ketone can cause defatting of the skin, leading to cracking, secondary infection, and dermatitis. This compound has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans. Methyl ethyl ketone has exhibited developmental toxicity in some animal tests

• Brandgefahr

  Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

• Flammability and Explosibility

  Methyl ethyl ketone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." MEK vapor forms explosive mixtures with air at concentrations of 1.9 to 11% (by volume). Carbon dioxide or dry chemical extinguishers should be used for MEK fires.

• Chemische Reaktivität

  Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• Pharmakologie

  Anticonvulsant activity was demonstrated in rats given orally a dose of 805 mg MEK/kg, which significantly delayed the onset of isonicotinic acid hydrazide-induced convulsions and provided 60% protection against electroshock convulsions, but failed to protect against metrazole convulsions (Kohli, Kishor, Dua & Saxena, 1967). Golubev (1969) reported that 0.25 M-MEK caused contraction of the rabbit pupil, and MEK and other volatile substances isolated from human urine and injected iv into rabbits damaged cerebral and coronary arteries and caused increased capillary permeability, but did not alter the blood-sugar level (Mabuchi, 1969). In dogs, MEK caused vomiting, muscular debility and the formation of large quantities of urinary magnesium ammonium phosphate crystals (Verstraete, van der Stock & Mattheeuws, 1964).
  Combined ip administration of MBK and MEK (1:3) to guinea-pigs increased the urinary excretion of the MBK metabolites 2-hexanol and 2,5-hexanedione (Couri, Abdel-Rahman & Hetland, 1976). If the neurotoxic action of MBK is mediated by a metabolite, stimulation of MBK metabolism by simultaneous exposure to MEK may help to explain the marked enhancement of neurotoxicity that is observed with combined MBK/MEK exposures (Hetland et al. 1976).

• Sicherheitsprofil

  Moderately toxic by ingestion, skin contact, and intraperitoneal routes. Human systemic effects by inhalation: conjunctiva irritation and unspecified effects on the nose and respiratory system. An experimental teratogen. A strong irritant. Human eye irritation @ 350 ppm. Affects peripheral nervous system and central nervous system. Highly flammable liquid. Reaction with hydrogen peroxide + nitric acid forms a heatand shock-sensitive explosive product. Ignition on contact with potassium tert-butoxide. Mixture with 2- propanol will produce explosive peroxides during storage. Vigorous reaction with chloroform + alkali. Incompatible with chlorosulfonic acid, oleum. To fight fire, use alcohol foam, CO2, dry chemical. Used in production of drugs of abuse. When heated to decomposition it emits acrid smoke and fumes.

• mögliche Exposition

  MEK is used as a solvent in nitrocellulose coating and vinyl film manufacture; in smokeless powder manufacture; in cements and adhesives and in the dewaxing of lubricating oils. It is also an intermediate in drug manufacture

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

• Carcinogenicity

  Although MEK has not been specifically examined in a rodent 2-year bioassay, there is little to suggest that the material is carcinogenic. When used as a delivery vehicle in a dermal carcinogenicity bioassay for organic sulfur compounds, Horton et al. found that the application of benzyl disulfide or phenylbenzylthiophene in a 25–29% solution of MEK in dodecylbenzene together failed to increase the incidence of benign skin papillomas in male C3H/HeJmice. The mice used in the experiments were treated twice a week for 52 weeks with the MEKcontaining test solution.

• Source

  Improper disposal of cleaning fluids, adhesives, paints, and lacquers, and laboratory solvent. Leaches from PVC cement used to join tubing (Wang and Bricker, 1979). Also present in cigarette smoke (500 ppm) and exhaust from gasoline-powered engines (<0.1–2.6 ppm) (Verschueren, 1983).
  Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered automobiles with and without catalytic converters were 0.47 and 32 mg/km, respectively (Schauer et al., 2002).
  Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of 2-butanone were 215 mg/kg of pine burned, 115 mg/kg of oak burned, and 77 mg/kg of eucalyptus burned.

• Environmental Fate

  Biological. Following a lag time of approximately 5 h, 2-butanone degraded in activated sludge (30 mg/L) at a rate constant ranging from 0.021 to 0.025/h (Urano and Kato, 1986).
  Bridié et al. (1979) reported BOD and COD values of 2.03 and 2.31 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. The ThOD for 2-butanone is 2.44 g/g. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM 2-butanone) and ThOD were 3.23 and 58.7%, respectively (Vaishnav et al., 1987).
  Photolytic. Synthetic air containing gaseous nitrous acid and exposed to artificial sunlight (λ = 300–450 nm) photooxidized 2-butanone into peroxyacetyl nitrate and methyl nitrate (Cox et al., 1980). They reported a rate constant of 2.6 x 10^-12 cm³/molecule?sec for the reaction of gaseous 2- butane with OH radicals based on a value of 8 x 10^-12 cm³/molecule?sec for the reaction of ethylene with OH radicals.
  The OH radical-initiated photooxidation of 2-butanone in a smog chamber produced peroxyacetyl nitrate and acetaldehyde (Cox et al., 1981). Reported rate constants for the reaction of 2-butanone with OH radicals in the atmosphere and in water are 1.15 x 10^-13 and 1.50 x 10^-13 cm³/molecule?sec, respectively (Wallington and Kurylo, 1987; Wallington et al., 1988a). The rate constant for the reaction of 2-butanone and OH radicals in the atmosphere at 300 K is 2.0 x 10^-12 cm³/molecule?sec (Hendry and Kenley, 1979). Cox et al. (1981) reported a photooxidation half-life of 2.3 d for the reaction of 2-butanone and OH radicals in the atmosphere.
  Chemical/Physical. 2-Butanone will not hydrolyze because it has no hydrolyzable functional group (Kollig, 1993).
  Combustion in air will produce carbon monoxide (incomplete combustion), carbon dioxide, and water vapor.
  At an influent concentration of 1.0 g/L, treatment with GAC resulted in an effluent concentration of 532 mg/L. The adsorbability of the carbon used was 94 mg/g carbon (Guisti et al., 1974).

• Lager

  2-Butanone should be protected from moisture.

• Versand/Shipping

  UN1193 Methyl ethyl ketone or Ethyl methyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.

• Toxicity evaluation

  There is very limited information on the mechanisms of toxicity of MEK. Relatively high-inhaled concentrations of 1475–29 500 mg m-3 (500–10 000 ppm) caused pulmonary vasoconstriction and hypertension in cats and dogs. There are several human case reports of neurological effects resulting from high exposure to MEK in combination with other solvents, and animal studies have confirmed synergism between MEK and ethyl n-butyl ketone, methyl n-butyl ketone, n-hexane, carbon tetrachloride, 2,5-hexanedione, and chloroform. The main target organs involved in toxicological interactions are the nervous system and liver, and the lung has also been mentioned.

• Inkompatibilitäten

  May form explosive mixture with air. Violent reaction with strong oxidizers, amines, ammonia, inorganic acids; caustics, isocyanates, pyridines. Incompatible with potassium tert-butoxide, 2-propanol, chlorosulfonic acid; oleum. Attacks some plastics. Ketones are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration

• Vorsichtsmaßnahmen

  2-Butanone vapor and air mixtures are explosive. It reacts violently with strong oxidants and inorganic acids causing fi re and explosion hazard.

2-Butanone Upstream-Materialien And Downstream Produkte

78-93-3, 2-Butanone Verwandte Suche: