6-Chlor-3-nitropyridin-2-ylamin

Bezeichnung:6-Chlor-3-nitropyridin-2-ylamin

CAS-Nr27048-04-0

Englisch Name:2-Amino-6-chloro-3-nitropyridine

CBNumberCB0245762

SummenformelC5H4ClN3O2

Molgewicht173.56

MOL-Datei27048-04-0.mol

Synonyma

6-Chlor-3-nitropyridin-2-ylamin

6-Chlor-3-nitropyridin-2-ylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	195-196
Siedepunkt	339.9±37.0 °C(Predicted)
Dichte	1.596±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Chloroform, DMSO
Aggregatzustand	Crystalline
pka	-1.69±0.50(Predicted)
Farbe	Yellow
Wasserlöslichkeit	Slightly soluble in water. Soluble in dimethyl sulfoxide and chloroform.
InChI	InChI=1S/C5H4ClN3O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H,(H2,7,8)
InChIKey	WERABQRUGJIMKQ-UHFFFAOYSA-N
SMILES	C1(N)=NC(Cl)=CC=C1[N+]([O-])=O
CAS Datenbank	27048-04-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-26-36/37/39
RIDADR	2811
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	29333999

Gefahreninformationscode (GHS)

2-Amino-6-chloro-3-nitropyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
2-Amino-6-chloro-3-nitropyridine is a cytotoxic drug that has been shown to have anti-viral potency, as well as antiviral activity in an activity test. It is synthesized by reacting hydrogen tartrate with oxadiazole, and then hydrolyzing the resulting product with chloride. 2-Amino-6-chloro-3-nitropyridine has also been shown to inhibit human immunodeficiency virus type 1 (HIV) replication in vitro and to be effective against other viruses such as type 2 influenza. This drug can bind to the viral envelope and inhibit fusion of the viral membrane with host cells by preventing the release of viral contents into the cytoplasm. The binding affinity of 2-amino 6-chloro 3 nitropyridine for chloride may be due to hydrogen bonding interactions.
Chemische Eigenschaften
YELLOW POWDER
Verwenden
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Synthese
The 2-Amino-6-chloro-3-nitropyridine may be obtained by the ammonolysis of 2,6-dichloro-3-nitropyridine by a known process. The ammonolysis is carried out by using solution of aqueous ammonia in methanol at 35°–40° C. After the reaction is over, the product is obtained by filtration.
Einzelnachweise
[1] Patent: CN103936766, 2016, B. Location in patent: Paragraph 0034-0035
[2] Patent: US2015/152057, 2015, A1. Location in patent: Paragraph 0111; 0112; 0113
[3] Patent: WO2009/27732, 2009, A1. Location in patent: Page/Page column 69-70
[4] Patent: WO2004/2986, 2004, A2. Location in patent: Page 127-128
[5] Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 11.1, p. 2420 - 2429

2-Amino-6-chloro-3-nitropyridine Upstream-Materialien And Downstream Produkte

6-Chlor-3-nitropyridin-2-ylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

27048-04-0, 2-Amino-6-chloro-3-nitropyridine Verwandte Suche:

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