ChemicalBook CAS DataBase List 127045-41-4

127045-41-4

Name	Pazufloxacin
CAS	127045-41-4
EINECS(EC#)	635-036-1
Molecular Formula	C16H15FN2O4
MDL Number	MFCD00865012
Molecular Weight	318.3
MOL File	127045-41-4.mol

Synonyms

(3S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID ALKALYL PAZUFLOXAXIN T-3761 (s)-yclopropyl)-9-fluoro-3-methyl-7-oxo Pazufloxacinmyesylate Pazufloxaxin mesilate PAZUFLOXACIN 98+% (S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Pazufloxacin318.3 Pazufloxacine PAZUFLOXACIN (PREPARATION FOR PAZUFLOXACIN MESILATE) PAZUFLOXACIN(ALKALYL) 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-(9CI) (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-(9CI) 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- (S)-10-(1-AMINOCYCLOPROPYL)-9-FLUORO-3-METHYL-7-OXO-3,7-DIHYDRO-2H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-

Chemical Properties

Melting point	269-271°C
alpha	D25 -88.0° (c = 0.5 in 0.05N aq NaOH)
Boiling point	531.5±50.0 °C(Predicted)
density	1.56
storage temp.	2-8°C
solubility	Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly)
form	neat
pka	5.05±0.40(Predicted)
color	Off-White to Pale Yellow
Major Application	clinical testing
InChI	1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1
InChIKey	XAGMUUZPGZWTRP-ZETCQYMHSA-N
SMILES	C[C@H]1COc2c3N1C=C(C(O)=O)C(=O)c3cc(F)c2C4(N)CC4
CAS DataBase Reference	127045-41-4(CAS DataBase Reference)

Safety Data

Hazard Codes	Xn,C,F
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R34:Causes burns. R11:Highly Flammable. less more
Safety Statements	S36/37:Wear suitable protective clothing and gloves . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S16:Keep away from sources of ignition-No smoking . less more
WGK Germany	3
RTECS	UU8815300
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral
Toxicity	LD50 i.v. in male mice: >500 mg/kg (Todo) less more

Raw materials And Preparation Products

Hazard Information

Originator

Toyama (Japan)

Uses

antibactierial

Uses

Pazufloxacin is a potential antimicrobial and/or antiviral agent.

Definition

ChEBI: LSM-5745 is a member of quinolines.

Brand name

Pasil, Pazucross

Pharmaceutical Applications

A tricyclic fluoroquinolone, formulated as mesylate and hydrochloride salts for oral or parenteral use or as a methane sulfonate (eye ointment).
It displays good activity in vitro against methicillin susceptible Staph. aureus (MIC 0.2 mg/L), but is inactive against Str. pyogenes, Str. pneumoniae (MIC ≥4 mg/L) and enterococci. L. pneumophila is inhibited by 0.03 mg/L. Activity against Enterobacteriaceae, fastidious Gram-negative bacilli, Ps. aeruginosa and Acinetobacter spp. is similar to that of ofloxacin. It is weakly active against Sten. maltophilia and Burkholderia cepacia (MIC c. 2 mg/L). Against M. tuberculosis, MICs range from 0.8 to 4 mg/L. It is inactive against anaerobes.
After oral doses of 100 or 400 mg, peak plasma concentrations range from 0.94 mg/L (100 mg) to 4.5 mg/L (400 mg) after <1 h. The apparent elimination half-life is around 2 h. Most of the administered dose is eliminated in urine, about 70% within 24 h. Four metabolites have been reported. In elderly patients, according to the renal function, the peak plasma concentration may be elevated (up to 5.6 mg/L) and significantly delayed (2–6 h). The plasma protein binding ranges from 17% to 28%.

storage

Store at -20°C

Material Safety Data Sheet(MSDS)

Questions And Answer

Well-known Reagent Company Product Information

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532; 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

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TAIYUAN RHF CO.,LTD.

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Sichuan Kulinan Technology Co., Ltd

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Tianjin heowns Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai HuanChuan Industry Co.,Ltd.

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Credit Asia Chemical Co., Ltd.

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LETOPHARM LIMITED

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Henan CoreyChem Co., Ltd

Telephone0371-86658258

Websitehttp://www.coreychem.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone021-61312847; 18021002903

Websitehttp://www.shyuanye.com

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127045-41-4

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Hazard Information

Originator

Uses

Uses

Definition

Brand name

Pharmaceutical Applications

storage

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

References

Well-known Reagent Company Product Information

Supplier

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