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147059-72-1

Supplier Related Products Identification Chemical Properties Raw materials And Preparation Products Hazard Information

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Identification

Name
TROVAFLOXACIN
CAS
147059-72-1
Synonyms
CP-99219
TROVAFLOXACIN
Trovan：CP-99219-27
7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-keto-1,8-naphthyridine-3-carboxylic acid
(1α，5α，6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2，4-difluomphenyl)-6-fluom-1，4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
Molecular Formula
C20H15F3N4O3
MDL Number
MFCD00871697
MOL File
147059-72-1.mol
Molecular Weight
416.35

Chemical Properties

Boiling point 
630.5±55.0 °C(Predicted)
density 
1.612±0.06 g/cm3(Predicted)
pka
5.80±0.70(Predicted)
CAS DataBase Reference
147059-72-1

Raw materials And Preparation Products

Raw materials
Methanesulfonic acid-->1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester-->3-Quinolinecarboxylic acid-->Dichlorodifluoromethane and difluoroethane azeotropic mixture

Hazard Information

Uses
Antibacterial.
Definition
ChEBI: A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiot c that was withdrawn from the market due to risk of liver failure.
Brand name
Trovan (Pfizer).
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