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119-36-8

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Identification

Name
Birch-Me
CAS
119-36-8
Synonyms
2-Carbomethoxyphenol
2-HYDROXYBENZOIC ACID METHYL ESTER
2-(methoxycarbonyl)phenol
analgit
BETULA OIL
BIRCH OIL
BIRCH OIL, SWEET
exagien
FEMA 2154
FEMA 2745
Flucarmit
Gaultheria oil
Linsal
METHYL 2-HYDROXYBENZOATE
METHYL HYDROXYBENZOATE
METHYLIS SALICYLAS
METHYL-O-HYDROXYBENZOATE
METHYL SALICYLATE
o-Hydroxybenzoic acid methyl ester
OIL OF WINTERGREEN
EINECS(EC#)
204-317-7
Molecular Formula
C8H8O3
MDL Number
MFCD00002214
Molecular Weight
152.15
MOL File
119-36-8.mol

Chemical Properties

Appearance
colourless liquid with an odour of wintergreen
Melting point 
-8 °C
mp 
-8 °C
Boiling point 
222 °C(lit.)

bp 
222 °C(lit.)

density 
1.174 g/mL at 25 °C(lit.)
vapor density 
5.26 (vs air)

vapor pressure 
1 mm Hg ( 54 °C)

refractive index 
n20/D 1.536(lit.)

FEMA 
2745
Fp 
226 °F

form 
Liquid
color 
Clear colorless to pale yellow
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility 
0.07 g/100 mL (20 ºC)
Merck 
14,6120
BRN 
971516
InChIKey
OSWPMRLSEDHDFF-UHFFFAOYSA-N
Contact allergens
This anti-inflammatory agent is found in a wide number of ointments and can induce allergic contact dermatitis.
CAS DataBase Reference
119-36-8(CAS DataBase Reference)
NIST Chemistry Reference
2-Hydroxybenzoic acid methyl ester(119-36-8)
EPA Substance Registry System
119-36-8(EPA Substance)

Hazard Information

Chemical Properties
colourless liquid with an odour of wintergreen
Definition
ChEBI: A benzoate ester that is the methyl ester of salicylic acid.
General Description
Colorless yellowish or reddish liquid with odor of wintergreen.
Reactivity Profile
METHYL SALICYLATE(119-36-8) is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This chemical is incompatible with oxidizers. METHYL SALICYLATE(119-36-8) is also incompatible with strong bases. METHYL SALICYLATE(119-36-8) may react with iron salts.
Air & Water Reactions
Insoluble in water.
Hazard
Toxic by ingestion; use in foods restrictedby FDA, lethal dose 30 cc in adults, 10 cc in chil-dren.
Health Hazard
Harmful if swallowed, inhaled, absorbed through skin. Vapor mist is irritating to the eyes, mucous membranes, upper respiratory tract and skin. Ingestion of relatively small amount causes severe poisoning and death. Causes nausea, vomiting, acidosis, pulmonary edema, pneumonia, convulsions and death.
Fire Hazard
This chemical is combustible.

Safety Data

Hazard Codes 
Xn
Risk Statements 
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin .
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
RIDADR 
3082
WGK Germany 
1

RTECS 
VO4725000


8
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29182300
Safety Profile
Human poison by ingestion. Moderately toxic to humans by an unspecified route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: flaccid paralysis without anesthesia, general anesthesia, dyspnea, nausea, vomiting, and respiratory stimulation. Experimental reproductive effects. A severe skin and eye irritant. Ingestion of relatively small amounts has caused severe poisoning and death. Combustible liquid when exposed to heat or flame; can react with oxibzing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazardous Substances Data
119-36-8(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 887 mg/kg (Jenner)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

msds information
Birch-Me(119-36-8).msds

Questions And Answer

description
Natural material is found in wintergreen oil, oil of wintergreen, birch oil, green tea seed oil, clove oil, Quercetin tree oil, tuberose oil, small when medicated oil, tea oil, ylang ylang oil and cherry, apple, strawberry fruit juice. It is colorless or pale yellow, red or light yellow transparent oily liquid. A strong aroma of wintergreen oil. Relative molecular mass of 152.16. The relative density of 1.1738. Melting point-8.6 ℃. Boiling point 223.3 ℃. A flash point of 96 ℃. The refractive index of 1.5360. It is insoluble in water, soluble in alcohol, ether, acetic acid and other common organic solvents. It is easy to change when exposed in air . Rat oral LD50887mg/kg.
Salicylic acid and methanol are heated to prepare it in the presence of sulfuric acid . Or it is made of stone STSP plant holly leaf through distillation.
Methyl salicylate can be used in the formulation of flavors, mainly for the deployment of ylang ylang, tuberose, chypre, acacia, fougere, orchids. But the most common use is perfuming toothpaste. IFRA has no restrictions. Methyl salicylate is recognized as GRAS by FEMA, FEMA number 2745, the European Council includes methyl salicylate in health artificial flavorants table which can be used in food without harm to human , the maximum amount is 8400mg/kg, ADI value is 0.5mg/kg.
Methyl salicylate can be used for food flavor formula, is a food flavor within China's GB2760-1996 provisions of the temporary use , ADI value of 0 to 0.5, is commonly used in the deployment of strawberry, vanilla, grapes and other fruit-flavor flavor for food and beer, but also flavor fructose, soft drinks.Methyl salicylate is also used as preservatives, pesticides, polishes, inks, paints, polyester dye carriers in industrial fields
application
Methyl salicylate ointment is a common dermatology drug with analgesic, anti-inflammatory, bactericidal effect. Because it can induce local irritation, it is rarely orally used.When spread in the skin,it is easily absorbed. Its liniments, ointments can be used for acute rheumatoid arthritis, low back pain and muscle pain, also itching and flavoring agents, flavoring agents, preservatives.
Uses
Appropriately use it as modifiers for some floral types , such as ylang ylang, magnolia, acacia, shy flower, tuberose, gardenia, bloom, sweet clover grass.It is mainly used for medicine and hygiene products such as toothpaste, tooth powder, mouthwash, talcum powder, carminative oil. Methyl salicylate can also be used for industrial products such as glue, glue paper, card paste, paste. It can also be used for food flavor,such as strawberries, grapes, walnuts, spearmint, spicy flavor as a special green gas.
Methyl salicylate is used as high-temperature heat carrier in dyeing industry .
The product has similar-Pyrola odor ,when used as a spice, it is often used as flavoring agent for pharmaceutical drugs and the pigmentum.It also has applications in blending spices, such as Quercetin trees in general flavors. Methyl salicylate is also used as solvents and intermediates for the manufacture of pesticides, fungicides, perfumes, paints, cosmetics, ink and dye fibers such help. Methyl salicylate reacts with ammonia to make salicylamide which is used for production of antipyretic analgesics salicylaldehyde ethyl amine ,and salicylamide itself is an anti-inflammatory drug. Methyl salicylate can be obtained by acetylation using acetylsalicylic acid methyl ester (C10H10O4, [580-02-9]). Add methyl salicylate and acetic anhydride into pot ,put sulfuric acid under stirring, the reaction temperature does not exceed 60 ℃ for about 1h, the reaction is completed, the reaction is poured into ice water and precipitated crystals are filtered, washed, dried, and acetylsalicylic acid methyl ester is obtained. Acetylsalicylic acid can be prepared by cyclization to get 4-hydroxy coumarin. Methyl salicylate is used as a pharmaceutical for external application agent.
Perfumes and suntan lotion ultraviolet absorber.
Production Method
Methyl salicylate is widespread in nature, and it is a main ingredient of wintergreen, small medicated oil . Alsoit is present in essential oils of the tuberose, Quercetin tree, ylang ylang, cloves, tea. Salicylic acid and methanol are used to make it in the presence of sulfuric acid through esterification. Salicylic acid is dissolved in methanol, add sulfuric acid, heat with stirring, the reaction time is 3h,90-100℃, cool to below 30 ℃,take oil ,wash with sodium carbonate solution to pH8 above, and then wash 1 time with water. Vacuum distillation, collect 95-110 ℃ (1.33-2.0kPa) distillate, obtain methyl salicylate. The yield is over 80%. General industrial methyl salicylate content is 99.5%. Material consumption fixed: Acid 950kg/t, methanol 400kg/t.

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