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1,1'-Carbonyldiimidazole

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1,1'-Carbonyldiimidazole Basic information
1,1'-Carbonyldiimidazole Chemical Properties
  • Melting point:117-122 °C(lit.)
  • Boiling point:288.83°C (rough estimate)
  • Density 1.303 g/mL at 25 °C
  • refractive index n20/D1.434
  • storage temp. 2-8°C
  • solubility Soluble in dimethylformamide.
  • pka2.90±0.10(Predicted)
  • form Crystalline Powder
  • color White to light cream
  • PH7.7 (50g/l, H2O, 20℃)
  • PH Range7.7 at 50 g/l
  • Water Solubility Insoluble in water
  • Sensitive Moisture Sensitive
  • Merck 14,1819
  • BRN 6826
  • Stability:Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
  • InChIKeyPFKFTWBEEFSNDU-UHFFFAOYSA-N
  • CAS DataBase Reference530-62-1(CAS DataBase Reference)
  • EPA Substance Registry System1H-Imidazole, 1,1'-carbonylbis- (530-62-1)
Safety Information
MSDS
1,1'-Carbonyldiimidazole Usage And Synthesis
  • Chemical PropertiesWhite crystalline powder
  • UsesUsed in the synthesis of peptides. Contains up to 10% imidazole.
  • Usespeptide coupling reagent
  • UsesCDI is mainly employed to convert alcohols and amines into carbamates, esters, and ureas. It is also used in the synthesis of peptides and nucleoside triphosphates.
  • Uses1,1'-Carbonyldiimidazole is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.
  • Purification MethodsCrystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]
1,1'-Carbonyldiimidazole Preparation Products And Raw materials
1,1'-Carbonyldiimidazole(530-62-1)Related Product Information
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