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Name Lithium diisopropylamide
CAS 4111-54-0
EINECS(EC#) 223-893-0
Molecular Formula C6H14LiN
MDL Number MFCD00064449
Molecular Weight 107.12
MOL File 4111-54-0.mol

Chemical Properties

Appearance dark yellow to orange or dark red-brown solution
Melting point  decomposes [MER06]
Boiling point  65 °C
density  0.864 g/mL at 25 °C(lit.)
vapor density  >1 (vs air)
Fp  91 °F
storage temp.  2-8°C
solubility  soluble in ethyl ether; insoluble in hydrocarbon solvents
form  liquid
color  brown
Water Solubility  decomposes
Sensitive  Air & Moisture Sensitive
Detection Methods T
Merck  3196
BRN  3655042
Lithium diisopropylamide is a sterically hindered nonnucleophilic strong base used for selective deprotonations, especially for the production of kinetic enolates (i.e., the thermodynamically less favored isomer) and (hetero-)aromatic carbanions. In the production of the serum lipid regulating agent Gemfibrozil one key intermediate is formed by quenching an ester enolate with 1-bromo-3-chloropropane.
CAS DataBase Reference 4111-54-0(CAS DataBase Reference)
Storage Precautions Air sensitive;Store under nitrogen;Moisture sensitive
EPA Substance Registry System 4111-54-0(EPA Substance)

Safety Data

Hazard Codes  C,N,F
Risk Statements 
R14:Reacts violently with water.
R17:Spontaneously flammable in air.
R34:Causes burns.
R67:Vapors may cause drowsiness and dizziness.
R65:Harmful: May cause lung damage if swallowed.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R35:Causes severe burns.
R19:May form explosive peroxides.
R15:Contact with water liberates extremely flammable gases.
R11:Highly Flammable.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R14/15:Reacts violently with water, liberating extremely flammable gases .
R40:Limited evidence of a carcinogenic effect.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .
S8:Keep container dry .
S16:Keep away from sources of ignition-No smoking .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S33:Take precautionary measures against static discharges .
S27:Take off immediately all contaminated clothing .
RIDADR  UN 3399 4.3/PG 2
WGK Germany  3
HazardClass  4.2
PackingGroup  I
HS Code  29211990

Hazard Information

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