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5,7-Dihydrox -4'-methoxyisoflavone
- русский язык имя
- английское имя5,7-Dihydrox -4'-methoxyisoflavone
- CAS №491-80-5
- CBNumberCB8474490
- ФормулаC16H12O5
- мольный вес284.26
- EINECS207-744-7
- номер MDLMFCD00006839
- файл Mol491-80-5.mol
химическое свойство
Температура плавления | 210-213 °C(lit.) |
Температура кипения | 340-355 °C(Press: 0.5 Torr) |
плотность | 1.420±0.06 g/cm3(Predicted) |
температура хранения | 2-8°C |
растворимость | acetone: 10 mg/mL, clear, brown |
пка | 6.50±0.20(Predicted) |
форма | Powder |
цвет | Off-White to Beige |
Растворимость в воде | Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C). |
λмакс | 263nm(EtOH)(lit.) |
БРН | 278107 |
LogP | 3.341 (est) |
Справочник по базе данных CAS | 491-80-5(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | biochanin A |
FDA UNII | U13J6U390T |
Система регистрации веществ EPA | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5) |
Заявления о безопасности | 22-24/25 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | DJ3002500 | |||||||||
F | 10 | |||||||||
TSCA | Yes | |||||||||
кода HS | 29329990 | |||||||||
NFPA 704: |
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5,7-Dihydrox -4'-methoxyisoflavone химические свойства, назначение, производство
Описание
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM).Химические свойства
Off-White SolidИспользование
An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyreneОбщее описание
Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel?Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion.5,7-Dihydrox -4'-methoxyisoflavone запасные части и сырье
5,7-Dihydrox -4'-methoxyisoflavone поставщик
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