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Cortisone acetate

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Cortisone acetate Basic information
Cortisone acetate Chemical Properties
  • Melting point:237-240 °C(lit.)
  • alpha D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
  • refractive index 212 ° (C=1, MeOH)
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
  • form neat
  • Merck 14,2539
  • BRN 2067543
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference50-04-4(CAS DataBase Reference)
  • EPA Substance Registry SystemPregn-4-ene-3,11, 20-trione, 21-(acetyloxy)-17-hydroxy- (50-04-4)
Safety Information
  • Safety Statements 22-36/37-24/25
  • WGK Germany 3
  • RTECS GM9140000
  • HS Code 32041200
Cortisone acetate Usage And Synthesis
  • Chemical Propertiessolid
  • UsesCortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).
  • General DescriptionCortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.
  • Purification MethodsCrystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]
Cortisone acetate Preparation Products And Raw materials
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