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CORTISONE

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CORTISONE Basic information
CORTISONE Chemical Properties
  • Melting point:223-228 °C (dec.)(lit.)
  • alpha D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
  • Boiling point:412.46°C (rough estimate)
  • Density 1.28±0.1 g/cm3 (20 ºC 760 Torr)
  • refractive index 210 ° (C=1, EtOH)
  • Flash point:9℃
  • storage temp. -20°C Freezer
  • pka12.37±0.60(Predicted)
  • Water Solubility 229.9mg/L(25 ºC)
  • Merck 2539
  • CAS DataBase Reference53-06-5(CAS DataBase Reference)
Safety Information
MSDS
CORTISONE Usage And Synthesis
  • Chemical PropertiesOff-White Crystalline Powder
  • UsesGlucocorticoid, anti-inflammatory agent
  • Usesantiinflammatory, glucocorticoid
  • UsesAnticoagulant
  • DefinitionChEBI: A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.
  • HazardDamaging side effects, e.g., sodium retention from ingestion.
  • Purification MethodsCrystallise cortisone from 95% EtOH or acetone. The UV has 14,000 M-1cm -1 at 237nm (EtOH). [Beilstein 8 IV 3480, Hems J Pharm Pharmacol 5 409 1953, Beilstein 8 IV 3480.]
CORTISONE Preparation Products And Raw materials
CORTISONE(53-06-5)Related Product Information
CORTISONESupplierMore
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