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Prednisone Basic information
Prednisone Chemical Properties
  • Melting point:236-238 °C(lit.)
  • alpha 169 º (c=0.5, dioxane)
  • Boiling point:410.86°C (rough estimate)
  • Density 1.1121 (rough estimate)
  • refractive index 170 ° (C=0.5, Dioxane)
  • Flash point:>200℃
  • storage temp. Refrigerator
  • solubility Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
  • pka12.36±0.60(Predicted)
  • Water Solubility 115mg/L(25 ºC)
  • Merck 7722
  • BRN 2065301
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference53-03-2(CAS DataBase Reference)
  • NIST Chemistry ReferencePrednisone(53-03-2)
  • EPA Substance Registry SystemPrednisone (53-03-2)
Safety Information
Prednisone Usage And Synthesis
  • Chemical PropertiesWhite or almost white, crystalline powder.
  • UsesAdrenocortical steroid. Glucocorticoid, antiinflammatory.
  • UsesDownregulates TNF-α production and NF-κB expression
  • DefinitionChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
  • brand nameCortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).
  • General DescriptionOdorless white crystalline powder.
  • General DescriptionPrednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
  • Air & Water ReactionsVery slightly water soluble .
  • HazardQuestionable carcinogen.
  • Safety ProfilePoison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
  • Purification MethodsCrystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]
Prednisone Preparation Products And Raw materials
Prednisone(53-03-2)Related Product Information
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
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  • Company Name:BeiJing Hwrk Chemicals Limted
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