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Salicylanilide

Product NameSalicylanilide
CAS87-17-2
MFC13H11NO2
MW213.23
EINECS201-727-8
MOL File87-17-2.mol

Chemical Properties

Melting point	136-138 °C (lit.)
Boiling point	353.22°C (rough estimate)
Density	1.1544 (rough estimate)
bulk density	455kg/m3
refractive index	1.5700 (estimate)
storage temp.	Store below +30°C.
solubility	H2O: slightly soluble
form	buffered aqueous glycerol solution
pka	7.11±0.10(Predicted)
color	White to Almost white
PH	7-7.5 (50g/l, H2O, 25℃)
biological source	goat
Water Solubility	SLIGHTLY SOLUBLE
Merck	14,8330
BRN	1108135
InChI	1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)
InChIKey	WKEDVNSFRWHDNR-UHFFFAOYSA-N
SMILES	Oc1ccccc1C(=O)Nc2ccccc2
CAS DataBase Reference	87-17-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzamide, 2-hydroxy-N-phenyl-(87-17-2)
EPA Substance Registry System	Salicylanilide (87-17-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-36
RIDADR	UN 3077 9 / PGIII
WGK Germany	2
RTECS	VN7850000
Autoignition Temperature	>300 °C
TSCA	TSCA listed
HazardClass	9
HS Code	29242995
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 2 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS

Provider	Language
N-Phenylsalicylamide	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Chemical Properties

greyish-brownish powder

Uses

Anti-mildew, fungicide.

Uses

antipyretic, fungicide

Uses

Salicylanilides are compounds of varying biological activity ranging from anti-inflammatory agents to antiviral and antimicrobial agents.

Definition

ChEBI: An amide of salicylic acid and of aniline; it is therefore both a salicylamide and an anilide.

General Description

Salicylanilide inhibited mycobacterial isocitrate lyase (ICL) and showed a significant antimycobacterial effect.

Hazard

Toxic by ingestion, irritant to skin.

Synthesis

Method for catalyzing the carbonylation of halogenated aromatic hydrocarbons, amines, and carbon monoxide to prepare salicylanilides comprising the steps of:

(1) dehydrating and deoxidizing the catalyst and the reaction substrate

, sealed and standby.

(2) Treatment of reaction atmosphere

The reactor in step (1) will be ultrasonic 15-30min, high-purity carbon monoxide will be flushed into the ball gallbladder standby, ultrasonic completed with a mechanical pump to replace the atmosphere in the reactor to carbon monoxide gas.

(3) The above-treated reactor was placed on a stirrer for 4-30 hours, and when the reaction was completed, the mixture was taken out in a ventilated kitchen, centrifuged, and the supernatant, which was a mixed solution containing the target product salicylanilide, was analyzed qualitatively and quantitatively by GC-MS and GC for the samples to be tested.

Salicylanilide

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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