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Salinomycin

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Salinomycin Basic information
Salinomycin Chemical Properties
  • Melting point:112.5-113.5 °C(lit.)
  • alpha D25 -63° (c = 1 in ethanol)
  • Boiling point:839.2±65.0 °C(Predicted)
  • Density 1.18±0.1 g/cm3(Predicted)
  • Flash point:>110°(230°F)
  • storage temp. 2-8°C
  • form White solid
  • pka6.4 (DMF)
  • Water Solubility Soluble in methanol. Insoluble in water
  • Merck 13,8415
  • Stability:Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference53003-10-4(CAS DataBase Reference)
Safety Information
MSDS
Salinomycin Usage And Synthesis
  • Chemical Propertiessolid
  • Usesantibacterial
  • UsesSalinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.
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