4-Methyl-2-pentanone Chemical Properties
- Melting point:-80 °C (lit.)
- Boiling point:117-118 °C
- Density 0.801 g/mL at 25 °C (lit.)
- vapor density 3.5 (vs air)
- vapor pressure 15 mm Hg ( 20 °C)
- refractive index n
- FEMA 2731 | 4-METHYL-2-PENTANONE
- Flash point:56 °F
- storage temp. Store at +5°C to +30°C.
- solubility water: soluble20g/L
- form Liquid
- color APHA: ≤15
- OdorPleasant; mild, characteristic; sharp; non-residual; ketonic.
- explosive limit1.2-8%, 93°F
- Odor Threshold0.17ppm
- Water Solubility 17 g/L (20 ºC)
- λmaxλ: 335 nm Amax: 1.00
λ: 340 nm Amax: 0.50
λ: 360 nm Amax: 0.15
λ: 380 nm Amax: 0.02
λ: 400 nm Amax: 0.01
- JECFA Number301
- Merck 14,5207
- BRN 605399
- Henry's Law Constant2.56 at 25 °C (batch stripping method-GC, Kim et al., 2000)
- Exposure limitsTLV-TWA 205 mg/m3 (50 ppm); STEL 300 mg/m3 (75 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).
- CAS DataBase Reference108-10-1(CAS DataBase Reference)
- NIST Chemistry ReferenceMethyl isobutyl ketone(108-10-1)
- IARC2B (Vol. 101) 2013
- EPA Substance Registry SystemMethyl isobutyl ketone (108-10-1)
- Hazard Codes F,Xn,T
- Risk Statements 11-20-36/37-66-39/23/24/25-23/24/25
- Safety Statements 9-16-29-45-36/37-7
- RIDADR UN 1245 3/PG 2
- WGK Germany 1
- RTECS SA9275000
- Autoignition Temperature840 °F
- TSCA Yes
- HS Code 2914 13 00
- HazardClass 3
- PackingGroup II
- Hazardous Substances Data108-10-1(Hazardous Substances Data)
- ToxicityLD50 orally in rats: 2.08 g/kg (Smyth)
4-Methyl-2-pentanone Usage And Synthesis
- Description4-Methyl-2-pentanone has a pleasant odor. May be prepared by hydrogenation of mesityl oxide over Ni at 160 - 190°C; also by oxidation of methyl isobutyl carbinol.
- Chemical Properties4-Methyl-2-pentanone has a fruity, ethereal, spicy (on dilution) odor.
- Chemical PropertiesMethyl isobutyl ketone (MIBK) is a colorless liquid with a pleasant, sweet, fruity odor. The odor threshold can be as low as 0.10 ppm. It is 2% soluble in water by weight and with several other organic solvents. The lower explosive limit is 1.2% and the upper explosive limit is 8.0% at 200 °F. Methyl isobutyl ketone may be incompatible with strong oxidizers and potassium tert-butoxide.
- Physical propertiesClear, colorless, watery liquid with a mild, pleasant odor. Odor threshold concentration is 47 ppbv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m3 (100 ppbv) and 1.1 mg/m3 (270 ppbv), respectively (Hellman and Small, 1974).
- OccurrenceReported found in orange and lemon juice, grape; vinegar, baked potato, papaya, ginger, wheat bread, cheeses, milk, cooked egg, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushroom, trassi, sesame seed, buckwheat, wort, elder flower, Bourbon vanilla, clary and red sage, crab, clam and Chinese quince.
- UsesMIBK is used as a solvent for gums, resins,nitrocellulose and cellulose ethers, and various fats, oils, and waxes.
- UsesIn paints, glues, and cleaning agents; used in the plastic and petrol industries
- UsesMethyl isobutyl ketone (hexone, isobutyl methyl ketone, 4-methyl-2-pentanone) is an organic solvent similar in structure and use to methyl butyl ketone. In addition to its use as a solvent for paints, lacquers, and varnishes, methyl isobutyl ketone is used in extraction processes and as a denaturant for rubbing alcohol. Methyl isobutyl ketone is also used as a synthetic flavoring in some varieties of rum, candy, and cheese. Unlike methyl butyl ketone, methyl isobutyl ketone has not been found to occur naturally.
- PreparationBy hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.
- Production MethodsMethyl isobutyl ketone can be manufactured by two processes . The first is a mixed ketone process where MiBK, diisobutyl ketone, and acetone are coproduced in a single reaction using isopropanol as a starting material. The second method is used to produce the majority of MiBK and involves a three-step reaction sequence in which diacetone alcohol and mesityl oxide are formed as intermediates.
- Aroma threshold valuesDetection: 240 to 640 ppb
- Taste threshold valuesTaste characteristics at 25 ppm: sweet, ethereal, banana and fruity with dairy nuances
- Synthesis Reference(s)Journal of the American Chemical Society, 100, p. 5437, 1978 DOI: 10.1021/ja00485a031
Tetrahedron Letters, 36, p. 2285, 1995 DOI: 10.1016/0040-4039(95)00191-E
Tetrahedron, 37, p. 3073, 1981 DOI: 10.1016/S0040-4020(01)98839-8
- General DescriptionA clear colorless liquid with a pleasant odor. Flash point 73°F. Less dense than water. Vapors heavier than air.
- Air & Water ReactionsHighly flammable. 4-Methyl-2-pentanone is sensitive to air (may form explosive peroxides). Slightly soluble in water.
- Reactivity Profile4-Methyl-2-pentanone is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. 4-Methyl-2-pentanone reacts violently with potassium tert-butoxide. 4-Methyl-2-pentanone reacts vigorously with reducing materials. .
- HazardFlammable, dangerous fire risk, explosivelimits in air 1.4–7.5%. Avoid ingestion and inhala-tion. Upper respiratory tract irritant, dizziness, andheadache. Possible carcinogen.
- Health HazardVapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them.
- Health HazardMIBK exhibits low to moderate toxicity.It is more toxic than acetone. Exposureto 200 ppm can cause irritation of theeyes, mucous membranes, and skin. Prolonged skin contact can leach out fat fromthe skin. Exposure to high concentrationscan cause nausea, headache, and narcosis. Animal studies indicate that this compound could probably cause kidney damage,with symptoms of a heavier kidney, higherkidney-to-body weight ratio, and tubularnecrosis. An increase in liver weight wasnoted, too, associated with its exposure inanimal subjects. In male rats the effect wasobserved at 2000 ppm on 2 weeks’ exposure(6 hours/day) (Phillips et al. 1987). Otherthan for the male rat kidney effect, the levelsup to 1000 ppm for 14 weeks had no significant toxicological effect. In another study,exposure to 3000 ppm in rats and mice wasfound to cause increased liver and kidneyweights, decrease in food consumption, incidence of dead fetuses, and reduced fetal bodyweight (Tyl et al. 1987).
Ingestion of MIBK can result in narcosis and coma. A genetic toxicology studyof MIBK showed a negative response inthe bacterial mutation assays and the yeastmitotic gene conversion assay (Brooks et al.1988).
LD50 value, oral (rat): 2080 mg/kg
LD50 value, intraperitoneal (rat): 400 mg/kg.
- Chemical ReactivityReactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
- Potential ExposureMIBK is used as a solvent; a denaturant; and as an extractant; in the manufacture of methyl amyl alcohol; as a solvent in paints, varnishes, and lacquers; as an alcohol denaturant; as a solvent in uranium extraction from fission products.
- CarcinogenicityThe National Toxicology Program
conducted cancer bioassays by exposing groups of
50 male and 50 female F344 rats and B6C3F1 mice to
MiBK vapor at 0, 450, 900, or 1800 ppm 6h/day, 5 days/
week for 2 years. Survival and body weight gain
were decreased in male rats at 1800 ppm. Body weight
gain was also decreased in male rats at 900 and in female
mice at 1800ppm. A higher incidence of mineralization of
the renal papilla was observed in male rats at all MiBK
exposure levels. Chronic progressive nephropathy (CPN) and
the incidences of adenoma and adenoma or carcinoma
(combined) were increased for the male 1800 ppm exposure
group. The severity of CPN and renal tubular hyperplasia was
increased in all male rat exposure groups. An uncertain
increase in mononuclear cell leukemia, adrenal medulla
hyperplasia, and a positive trend for increases in benign or
malignant pheochromocytomas (combined) were reported
for the 1800 ppm male group. The NTP considered that there
was some evidence of carcinogenic activity in male rats
based on increased incidences of renal tubule neoplasms.
None of the rodent bioassay results were considered clear evidence of carcinogenicity by NTP.
- Environmental FateBiological. Bridié et al. (1979) reported BOD and COD values of 2.06 and 2.16 g/g using
filtered effluent from a biological sanitary waste treatment plant. These values were determined
using a standard dilution method at 20 °C and stirred for a period of 5 d. Heukelekian and Rand
(1955) reported a 5-d BOD value of 1.51 g/g which is 55.5% of the ThOD value of 2.72 g/g.
Photolytic. When synthetic air containing gaseous nitrous acid and 4-methyl-2-pentanone was exposed to artificial sunlight (λ = 300–450 nm), photooxidation products identified were acetone, peroxyacetal nitrate, and methyl nitrate (Cox et al., 1980). In a subsequent experiment, the OHinitiated photooxidation of 4-methyl-2-pentanone in a smog chamber produced acetone (90% yield) and peroxyacetal nitrate (Cox et al., 1981). Irradiation at 3130 ? resulted in the formation of acetone, propyldiene, and free radicals (Calvert and Pitts, 1966).
Second-order photooxidation rate constants for the reaction of 4-methyl-2-butanone and OH radicals in the atmosphere are 1.4 x 10-10, 1.42 x 10-10, and 1.32 x 10-10 cm3/molecule?sec at 295, 299, and 300 K, respectively (Atkinson, 1985). The atmospheric lifetime was estimated to be 1–5 d (Kelly et al., 1994).
Photolytic. Cox et al. (1980) reported a rate constant of 1.24 x 10-11 cm3/molecule?sec for the reaction of gaseous 4-methyl-2-pentanone with OH radicals based on a value of 8 x 10-12 cm3/molecule?sec for the reaction of ethylene with OH radicals.
Chemical/Physical. 4-Methyl-2-pentanone will not hydrolyze in water because it does not contain a hydrolyzable functional group (Kollig, 1993).
- ShippingUN1245 Methyl isobutyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.
- Purification MethodsReflux the ketone with a little KMnO4, wash it with aqueous NaHCO3, dry with CaSO4 and distil it. Acidic impurities are removed by passage through a small column of activated alumina. [Beilstein 1 IV 3305.]
- IncompatibilitiesAble to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide; strong acids; aliphatic amines; reducing agents
- Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.
4-Methyl-2-pentanone Preparation Products And Raw materials
- Raw materialsAcetoneHydrogen4-Methyl-2-pentanolFERTILIZERZIRCONIUM(IV) HYDROGENPHOSPHATE
- Preparation ProductsPyrocatechol4,5-DIAMINO-6-METHYLPYRIMIDINEMilrinoneDomperidone2,2'-Azobis(2,4-dimethyl)valeronitrileLoperamideGestodene1-(3,4-Dichlorophenyl)piperazinePropiconazoleOxatomideN-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamineFosinoprilRanitidine hydrochloridePOTASSIUM HEPTAFLUOROTANTALATE(V)Niobium oxide (1H-INDAZOL-3-YL)-ACETIC ACID3,5-DIMETHYL-1-HEXYN-3-OLIMIBENCONAZOLE2-(MORPHOLINE-4-CARBONYL)-BENZOIC ACID(1,3-DIMETHYL-BUTYL)-HYDRAZINE2,3,6-Trimethylphenol
- 4-Methyl-2-pentanol 3-Methyl-2-butanone Fluvoxamine maleate (3S)-3-FMOC-AMINO-1-DIAZO-4-METHYL-2-PENTANONE [R,(+)]-2-Methoxy-4-methyl-3-pentanone [S,(+)]-1-(4-Bromophenyl)-3-methyl-1-pentanone 2,2-DIMETHYLCYCLOPENTANONE 1,1'-[2-Fluoro-2-nitro-1,3-propanediylbis(oxy)]bis[1,1-difluoro-4-methyl-3-pentanone] 4-((2-Furylmethyl)thio)-4-methylpentan-2-one 1-(4-Chlorophenyl)-4,4-dimethyl-3-pentanone (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(benzyloxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanone 1-Hydroxy-4-methyl-3-pentanone Methyl cyclopentenolone Parathion-methyl Norgestrel Chloromethyl isopropyl carbonate METHYL PERFLUOROBUTYL ETHER Methyl
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