2-Amino-5-fluoropyridine

Light yellow Cryst

2-Amino-5-fluoropyridine is used in chemical microarrays to identify ligands that binds pathogenic cells. Acts as a reagent in the preparation of heterocyclic compounds as integrase inhibiting antiviral agents.

ChEBI: 2-Amino-5-fluoropyridine is a dihydropyridine.

2-Amino-5-fluoropyridine is a versatile fluorinated pyridine building block widely used to prepare peptide deformylase inhibitors such as the antibacterial agent LBM415, as well as herbicides, fungicides, and PET imaging probes; the combined electron-withdrawing fluorine and nucleophilic amino substituents enhance metabolic stability and bioavailability of the resulting active pharmaceutical or agrochemical ingredients.

2-Amino-5-fluoropyridine is an important intermediate for the synthesis of LBM415 which is the peptide deformylas inhibitor. Using 2-aminopyridine as raw material and via nitrification, amino acetylation, reduction of nitro, diazolization, Schiemann reaction and hydrolysis of acetyl.

[1] E. S. HAND, D. C. BAKER. “ChemInform Abstract: Syntheses of 2-Chloro- and 2-Amino-5-fluoropyridines and Isolation of a Novel Difluoroboryl Imidate.” ChemInform 21 19 (1990).