Chemical Properties
Light yellow Cryst
Uses
2-Amino-5-fluoropyridine is used in chemical microarrays to identify ligands that binds pathogenic cells. Acts as a reagent in the preparation of heterocyclic compounds as integrase inhibiting antiviral agents.
Definition
ChEBI: 2-Amino-5-fluoropyridine is a dihydropyridine.
Synthesis
2-Amino-5-fluoropyridine is an important intermediate for the synthesis of LBM415 which is the peptide deformylas inhibitor. Using 2-aminopyridine as raw material and via nitrification, amino acetylation, reduction of nitro, diazolization, Schiemann reaction and hydrolysis of acetyl.
References
[1] E. S. HAND, D. C. BAKER. “ChemInform Abstract: Syntheses of 2-Chloro- and 2-Amino-5-fluoropyridines and Isolation of a Novel Difluoroboryl Imidate.” ChemInform 21 19 (1990).
