Chemical Properties
Crystallized from isopropanol, melting point 115-116°C. 5% ethanol solution is colorless, but turns green after exposure to air for 20h. Acute toxicity LD50 mice, rats (mg/kg): 617, 1660 oral. Flupirtine Hydrochloride (Flupirtine Hydrochloride): C15 H17FN4O2HCl. crystallized from water, melting point 214-215°C. Flupirtine Maleate (Flupirtine Maleate): C15H17FN4O2C4H4O4.[75507-68-5]. Colorless crystals from isopropanol, melting point 175.5 to 176°C. A mixture of crystalline A and B; preferably containing 60%-90% A.
Uses
Therapeutic use of Flupirtine was discontinued due to drug induced liver injury (DILI). Since the mechanism of action is not related to its adverse effects, it is important to focus on chemical modifications.
Definition
ChEBI: N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester is an aminopyridine.
Clinical Use
Flupirtine maleate is an
analgesic with an unknown mode of action. It is
used in single doses of 100 mg orally and 150
mg rectally for the treatment of different pain
conditions.
