3,4,5-Trimethoxytoluene was used as a substructure model compound in the reaction of trimethoprim with free available chlorine (i.e. HOCl).
3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.
Using 3,4,5-trimethoxybenzaldehyde as the starting material, referring to the synthesis method of Example 2, 10 g of 3,4,5-trimethoxybenzaldehyde was dissolved in 100 g of tetrahydrofuran, 1 g of Catalyst B was added, and the hydrogenation reaction was carried out under hydrogen atmosphere. Upon completion of the reaction, the aldehyde group conversion was confirmed to be 100% by testing. The isolated yield of the target product 3,4,5-trimethoxytoluene was 96% based on the initial addition of 3,4,5-trimethoxybenzaldehyde.
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