ChemicalBook > Product Catalog > Flavors and fragrances > Synthetic fragrances > Carboxylic acids and esters > Aliphatic dicarboxylic acid esters > Methyl propionate
Methyl propionate Chemical Properties
- Melting point:-88 °C (lit.)
- Boiling point:79 °C (lit.)
- Density 0.915 g/mL at 25 °C (lit.)
- vapor density 3 (vs air)
- vapor pressure 40 mm Hg ( 11 °C)
- refractive index n
- FEMA 2742 | METHYL PROPIONATE
- Flash point:43 °F
- storage temp. Store below +30°C.
- solubility H2O: soluble16 parts
- form Liquid
- color Clear colorless
- explosive limit2.5-13%(V)
- Water Solubility 5 g/100 mL at 20 ºC
- Merck 14,6112
- JECFA Number141
- BRN 1737628
- Stability:Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, bases. Readily forms explosive mixtures with air. Moisture sensitive.
- CAS DataBase Reference554-12-1(CAS DataBase Reference)
- NIST Chemistry ReferencePropanoic acid, methyl ester(554-12-1)
- EPA Substance Registry SystemMethyl propionate (554-12-1)
- Hazard Codes F,Xn
- Risk Statements 11-20-2017/11/20
- Safety Statements 16-24-29-33
- RIDADR UN 1248 3/PG 2
- WGK Germany 1
- RTECS UF5970000
- Autoignition Temperature876 °F
- TSCA Yes
- HS Code 2915 50 00
- HazardClass 3
- PackingGroup II
- Hazardous Substances Data554-12-1(Hazardous Substances Data)
- ToxicityLD50 orally in Rabbit: 5000 mg/kg
Methyl propionate Usage And Synthesis
- DescriptionMethyl propionate is an organic compound belonging to the family of carboxylic acid esters, which is commonly applied as a solvent for cellulose nitrate and lacquers. It also serves as a raw material in organic synthesis for manufacturing paints, varnishes and other chemical productions such as methyl methacrylate. Besides, the fruity smell and taste of methyl propanoate results in its usage of fragrances and flavoring agents.
Methyl propanoate can be synthesized by esterifying propionic acid with methanol. In the field of industry, it is produced by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl.
- DescriptionMethyl propionate, also known as methyl propanoate, is a chemical compound with the molecular formula C4H8O2. It is a volatile ester with a sweet, fruity, rum-like odor.
- Chemical Propertiescolourless liquid
- Chemical PropertiesMethyl propionate is colorless liquid with a sweet, fruity, rum-like odor.
- Chemical PropertiesMethyl propionate has a fruity odor reminiscent of rum with a sweet flavor suggestive of black currant. May be prepared by direct esterification of the acid with methanol in the presence of concentrated H2S04.
- Chemical PropertiesMethyl propionate has a fruity odor reminiscent of rum. It has a sweet flavor suggestive of black currant
- OccurrenceReported found in guava, honey, melon, pineapple, raspberry, blackberry, strawberry, cheddar cheese, cooked beef, coffee, soy protein, durian (Durio zibethinus), starfruit, plum brandy, cherimoya, kiwifruit, naranjilla, mussels and rooibus tea (Aspalathus linearis)
- UsesMethyl propionate is used as a solvent for cellulose nitrate and lacquers, and as a raw material for the production of paints, varnishes and other chemicals such as methyl methacrylate.
Due to its fruity smell and taste, it is also used in fragrances and flavoring.
- UsesIt is commonly used in organic synthesis. It undergoes vapor-phase aldol condensation with formaldehyde to form methyl methacrylate.
- UsesIn organic synthesis.
- PreparationMethyl propionate can be prepared by esterification of propionic acid with methanol. Industrially, it is prepared by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl.
- Production MethodsMethyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid .
- Aroma threshold valuesDetection: 100 ppb to 8.8 ppm
- General DescriptionA clear colorless liquid. Flash point 28°F. Density about the same as water. Vapors heavier than air. May irritate skin, eyes, and mucous membranes. Used for flavoring and as a solvent.
- Air & Water ReactionsHighly flammable. Soluble in water.
- Reactivity ProfileMethyl propionate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated with alkali metals and hydrides.
- HazardFlammable, dangerous fire risk, explosivelimits in air 2.5–13%.
- Health HazardMay cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
- Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
- Safety ProfileModerately toxic by ingestion. Mildly toxic by inhalation. A skin irritant. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
- Chemical SynthesisBy direct esterification of the acid with methanol in the presence of concentrated H2SO4
- Potential ExposureUsed as a solvent; and in making paints, lacquers, and varnishes. Also used in flavorings and fragrances
- ShippingUN1248 Methyl propionate, Hazard Class: 3; Labels: 3-Flammable liquid.
- Purification MethodsWash the ester with saturated aqueous NaCl, then dry it with Na2CO3 and distil it from P2O5. (This removes any free acid and alcohol.) It has also been dried with anhydrous CuSO4. [Beilstein 2 IV 104.]
- IncompatibilitiesMay form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Keep away from heat and moisture.
Methyl propionate Preparation Products And Raw materials
- Raw materialsPropionic acid
- Preparation ProductsMetalaxylPentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)RamiprilN-Benzyl-4-piperidone1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOLProcymidoneMethyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochlorideBenalaxylefficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagentCYANOACRYLIC ACID METHYL ESTEREthyl 2-chloropropionatehydrazide4-Amino-6-chloropyrimidineCARBETAMIDEBORONALMethyl 3-methylthiopropionateDICLOFOP-METHYLCIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID DIMETHYL ESTERDisperse Red 127
Ethyl propionate methyl 3-amino-2-[(3-hydroxy-4-methoxyphenyl)methyl]propanoate methyl 3-amino-2-[(3,4-difluorophenyl)methyl]propanoate [5-[(4-CHLOROPHENYL)SULFANYL]-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]METHYL PROPIONATE [5-[(2-CHLOROBENZYL)SULFONYL]-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]METHYL PROPIONATE Methyl 2-chloropropionate Methyl 2,3-dichloropropionate METHYL THIOPHENE-2-CARBOXYLATE Methyl Ethyl 2-bromopropionate Ethyl 2-bromohexanoate Ethyl 2-bromoisobutyrate DL-Ethyl 2-bromobutyrate Ethyl 2,3-dibromopropionate Ethyl 2-bromoheptanoate Ethyl 2-bromovalerate Parathion-methyl (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER
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