2,5-Dimethylpyridine

2,5-Lutidine was used to displace CO from the haem iron.

Tetrahedron Letters, 17, p. 383, 1976 DOI: 10.1016/S0040-4039(00)93738-9

The FT-IR and FT-Raman spectra of 2,5-lutidine was studied.

Steam distil the lutidine from a solution containing 1-2 equivalents of 20% H2SO4 until about 10% of the base has been carried over with the non-basic impurities, then the acidic solution is made alkaline, and the base is separated, dried with NaOH and fractionally distilled twice. Dry the distillate with Na and fractionally distil it through a Todd column (p 11) packed with glass helices. The hydrochloride has m 219o(dec), and the picrate has m 170.5o (from EtOH or H2O). [Beilstein 20 H 244, 20 II 160, 20 III/IV 2774, 20/6 V 27.]