ChemicalBook > Product Catalog > API > Digestive system drugs > Antacid and Mucosal protective Drugs > Dimethicone
Dimethicone Chemical Properties
- Density 1 g/mL at 20 °C
- vapor pressure 5 mm Hg ( 20 °C)
- refractive index n
- Flash point:121 °C
- solubility Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, miscible with ethyl acetate, with methyl ethyl ketone and with toluene.
- form neat
- Stability:Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, organics, acids, alkalis. Corrodes many metals.
- CAS DataBase Reference9006-65-9
- EPA Substance Registry SystemDimethicone (9006-65-9)
Dimethicone Usage And Synthesis
- Physical and chemical propertiesDimethyl silicone is also known as methyl silicone oil and polydimethylsiloxane liquid. It appears as colorless transparent viscous liquid, being tasteless, odorless and non-toxic. The molecular formula is CH3 [Si (cH3) 2] nSi (CH3) 3. The average molecular weight is 5000 ~ 100000. Based on the differences on the molecular weight, kinematic viscosity varies from 1.0 × 10-6 ~ 100000 × 10-6 square meters / second. Long-term use temperature range is -50 ~ 180 ℃. In isolated air or inert gas, it can be subject to long-term use at 200 ℃. Viscosity coefficient: 0.31 ~ 0.61. Surface tension: 1.59 ~ 2.15 × 10-4N / cm. Dielectric constant (23 ℃, 100Hz): 2.18 ~ 2.17. Volume resistivity (23 °C): 1.0 × 1014 to 1.0 × 1016Ωcm3. Dielectric loss tangent (23 ℃, 100Hz):0.00002~0.00004. Breakdown voltage strength: 13.7 ~ 17.7kV / mm. It is soluble in benzene, toluene, xylene and ethyl ether, partially soluble in ethanol, butanol and acetone, insoluble in cyclohexanol, methanol, paraffin oil and vegetable oil. It has excellent hydrophobic moisture resistance, good light transmission, and chemical stability. Widely used in insulation, heat, moisture-proof filler, defoamer, mold release agent, lubricant and surface treatment agent. It is produced by the reaction between octamethylcyclotetrasiloxane and hexamethyldisiloxane in the presence of concentrated sulfuric acid or tetramethylammonium hydroxide catalyst.
- ToxicityIt has no obvious acute and chronic poisoning reaction to human beings and mammals, nor be mutagenic and carcinogenic. Oral, inhalation and skin contact have no obvious irritation or allergic reaction to the eyes, skin, and can’t be absorbed by the gastrointestinal tract and skin.
- Chemical Propertiescolourless to slightly yellow liquid
- Chemical PropertiesDimethicones are clear, colorless liquids available in various viscosities.
- UsesA silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products.
- Usesdimethicone is a form of silicone used to give products lubricity, slip, and good feel. It can also serve as a formulation defoamer and help reduce the feeling of greasiness that some creams leave on the skin immediately upon application. In addition, dimethicone is reported to protect the skin against moisture loss when used in larger quantities. It improves product flow and spreadability. In combination with other ingredients, dimethicone becomes a good waterproofing material for sunscreen emulsions, and helps reduce the greasiness often seen in high-SPF preparations.
- IndicationsSilicone (dimethicone) ointments are excellent water-protective agents because they have an extremely low surface tension and penetrate crevices in the skin to form a plastic-like barrier. Further, they are nontoxic, inert, stable, and water repellent. As such, they are useful as barrier creams in industry or wherever constant or frequent exposure to aqueous compounds is a problem. They will not, however, protect well against solvents, oils, or dusts.
- DefinitionChEBI: A polydimethylsiloxane macromolecule, composed of dimethylsiloxane repeating units.
- Production MethodsDimethicone isapoly (dimethylsiloxane) obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. The hydrolysis products contain active silanol groups through which condensation polymerization proceeds. By varying the proportions of chlorotrimethylsilane, which acts as a chain terminator, silicones of varying molecular weight may be prepared. Different grades of dimethicone are produced that may be distinguished by a number placed after the name indicating the nominal viscosity. For example, ABIL 20 (Evonik Goldschmidt UK Ltd) has a nominal kinematic viscosity of 18–22mm2/s (18–22cSt).
- brand nameSentry Dimethicone (Witco); Sentry Dimethicone Dispension (Witco).
- Pharmaceutical ApplicationsDimethicones of various viscosities are widely used in cosmetic and pharmaceutical formulations. In topical oil-in-water emulsions dimethicone is added to the oil phase as an antifoaming agent. Dimethicone is hydrophobic and is also widely used in topical barrier preparations. Therapeutically, dimethicone may be used with simethicone in oral pharmaceutical formulations used in the treatment of flatulence. Dimethicone is also used to form a waterrepellent film on glass containers.
- SafetyDimethicone is generally regarded as a relatively nontoxic and nonirritant material although it can cause temporary irritation to the eyes. In pharmaceutical formulations it may be used in oral and topical preparations. Dimethicones are also used extensively in cosmetic formulations and in certain food applications.
The WHO has set a tentative estimated acceptable daily intake of dimethicone with a relative molecular mass in the range of 200–300 at up to 1.5mg/kg body-weight.
Injection of silicones into tissues may cause granulomatous reactions. Accidental intravascular injection has been associated with fatalities.
- storageDimethicones should be stored in an airtight container in a cool, dry, place; they are stable to heat and are resistant to most chemical substances although they are affected by strong acids. Thin films of dimethicone may be sterilized by dry heat for at least 2 hours at 160°C. Sterilization of large quantities of dimethicone by steam autoclaving is notrecommended since excesswater diffuses intothe fluid causing it to become hazy. However, thin films may be sterilized by this method. Gamma irradiation may also be used to sterilize dimethicone. Gamma irradiation can, however, cause crosslinking with a consequent increase in the viscosity of fluids.
- Regulatory StatusAccepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets, topical creams,emulsions,lotions,and transdermal preparations).Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Dimethicone Preparation Products And Raw materials
- Silicone oil Poly(dimethylsiloxane) Emulsified silicone oil CYCLOMETHICONE 4 (200 MG) Tosylmethyl isocyanide COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ferric acetylacetonate TERT-BUTYL ISOCYANIDE BENZYL ISOCYANIDE Cupric acetylacetonate SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) COBALT ETHYLENE DIAMINE CHLORIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE Aluminum acetylacetonate METHYL ISOCYANOACETATE
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