tert-Butyl bromoacetate CAS#: 5292-43-3

tert-Butyl bromoacetate

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tert-Butyl bromoacetate Basic information

tert-Butyl bromoacetate Chemical Properties

Melting point:44-47 °C
Boiling point:50 °C10 mm Hg(lit.)
Density 1.338
refractive index n20/D 1.445(lit.)
Flash point:121 °F
storage temp. 0-6°C
form Liquid
color Clear colorless to yellow
Specific Gravity1.333 (20/4℃)
Water Solubility Miscible with ethanol, chloroform and ethyl acetate. Immiscible with water.
Sensitive Lachrymatory
BRN 1753010
InChIKeyBNWCETAHAJSBFG-UHFFFAOYSA-N
CAS DataBase Reference5292-43-3(CAS DataBase Reference)
NIST Chemistry ReferenceAcetic acid, bromo-, 1,1-dimethylethyl ester(5292-43-3)
EPA Substance Registry SystemAcetic acid, bromo-, 1,1-dimethylethyl ester (5292-43-3)

Safety Information

MSDS

tert-Butyl bromoacetate Usage And Synthesis

Chemical Propertiesclear colorless to yellow liquid
Usestert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
Purification MethodsDissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.]

tert-Butyl bromoacetate Preparation Products And Raw materials

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