ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluoroaniline series 2,4-Difluoroaniline

2,4-Difluoroaniline

Product Name2,4-Difluoroaniline
CAS367-25-9
MFC6H5F2N
MW129.11
EINECS206-687-5
MOL File367-25-9.mol

Chemical Properties

Melting point	-7.5 °C (lit.)
Boiling point	170 °C/753 mmHg (lit.)
Density	1.268 g/mL at 25 °C (lit.)
refractive index	n20/D 1.506(lit.)
Flash point	145 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Not miscible or difficult to mix.
form	Liquid
pka	3.26±0.10(Predicted)
Specific Gravity	1.284 (20/4℃)
color	Clear brown
Water Solubility	1-5 g/100 mL at 20.55 ºC
Merck	14,3147
BRN	2802556
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
InChI	1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
InChIKey	CEPCPXLLFXPZGW-UHFFFAOYSA-N
SMILES	Nc1ccc(F)cc1F
LogP	1.7 at 25℃ and pH5-9
CAS DataBase Reference	367-25-9(CAS DataBase Reference)
NIST Chemistry Reference	2,4-Difluoroaniline(367-25-9)
EPA Substance Registry System	2,4-Difluoroaniline (367-25-9)

Safety Information

Hazard Codes	Xn,T,Xi
Risk Statements	20/21/22-36/37/38
Safety Statements	28-36/37/39-26-36
RIDADR	UN 2941 6.1/PG 3
WGK Germany	1
RTECS	BX3680000
F	8-9-23
Hazard Note	Toxic
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	III
HS Code	29214210
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 4 Oral

MSDS

Provider	Language
1-Amino-2,4-difluorobenzene	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Description

2,4-difluoroaniline is an important intermediate used in organic synthesis, pharmaceuticals agrochemicals, dyes, and agricultural chemicals.

Reference

R. Garth Pews, J. A. Gall, Process and intermediates for the preparation of 2,6-difluoroaniline, Paten US5041674A

Chemical Properties

dark red liquid

Uses

2,4-Difluoroaniline is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

General Description

Dark reddish-purple liquid.

Air & Water Reactions

2,4-Difluoroaniline may be sensitive to prolonged exposure to air. . Water soluble.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: 2,4-Difluoroaniline may be irritating to tissues.

Fire Hazard

2,4-Difluoroaniline is combustible.

Synthesis

446-35-5

367-25-9

The general procedure for the synthesis of 2,4-difluoroaniline from 2,4-difluoronitrobenzene was as follows: 2,4-difluoro-1-nitrobenzene (1 g), methanol (10 mL), and Pd/C catalyst (100 mg) were added to a 100 mL single-necked reaction flask. Subsequently, the reaction system was replaced three times with hydrogen to remove air. The reaction mixture was stirred at room temperature for 2-3 hours. Upon completion of the reaction, the catalyst was removed by filtration under reduced pressure and the filtrate was concentrated to give 810 mg of the target product 2,4-difluoroaniline.

References

[1] Synthetic Communications, 2012, vol. 42, # 2, p. 213 - 222
[2] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 1, p. 114 - 119
[3] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111
[4] Chemische Berichte, 1937, vol. 70, p. 2396,2400

2,4-Difluoroaniline

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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