ChemicalBook Product Catalog Organic Chemistry Inorganic acid Esters Diethyl phosphite

Diethyl phosphite

Product NameDiethyl phosphite
CAS762-04-9
MFC4H11O3P
MW138.1
EINECS212-091-6
MOL File762-04-9.mol

Chemical Properties

Melting point	-70 °C
Boiling point	50-51 °C/2 mmHg (lit.)
Density	1.072 g/mL at 25 °C (lit.)
vapor pressure	7hPa at 20℃
refractive index	n20/D 1.407(lit.)
Flash point	180 °F
form	Liquid
color	Colorless
Specific Gravity	1.072
Water Solubility	miscible (hydrolysis)
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	605759
Henry's Law Constant	1.7×10⁰ mol/(m³Pa) at 25℃, HSDB (2015)
Stability	Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible.
InChI	1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3
InChIKey	MJUJXFBTEFXVKU-UHFFFAOYSA-N
SMILES	[H]P(=O)(OCC)OCC
LogP	-0.15
CAS DataBase Reference	762-04-9(CAS DataBase Reference)
NIST Chemistry Reference	Phosphonic acid, diethyl ester(762-04-9)
EPA Substance Registry System	Diethyl phosphite (762-04-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-43
Safety Statements	26-36/37/39-37/39-28-27
WGK Germany	1
RTECS	TG7875000
F	10-13-21
TSCA	TSCA listed
REACH Registrations	Active
HS Code	29209014
Storage Class	10 - Combustible liquids
Hazard Classifications	Eye Dam. 1 Skin Sens. 1B
Hazardous Substances Data	762-04-9(Hazardous Substances Data)

MSDS

Provider	Language
Diethyl hydrogen phosphonate	English
SigmaAldrich	English
ALFA	English

Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Diethyl phosphite is precursor used for the synthesis of various organophosphorus compounds. used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.

Uses

Diethyl phosphite (DEPI) is a versatile reactive intermediate used in the production of various phosphorus based substances. It may be used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.
It may be used:

in the stereoselective synthesis of β-fluorinated alkylphosphonates
Used in synthesis of homoallylic bromide
Used in synthesis of series of carbazole-based α-aminophosphonates
used as an extraction agent and phosphate intermediate.
Used in synthesis of pesticides kitazine and phosethyl-Al as well as synthetic O, O-diethyl phosphoryl chloride.
used for the synthesis of plasticizers, flame retardants, etc.
Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Definition

ChEBI: A phosphonic ester that is the diethyl ester of phosphonic acid.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 3327, 1988 DOI: 10.1016/0040-4039(88)85153-0

Synthesis Reference(s)

Synthetic Communications, 18, p. 665, 1988 DOI: 10.1080/00397918808077352

General Description

Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Diethyl phosphite

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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