Diethyl phosphite

Chemical Properties

colourless liquid

Uses

Diethyl phosphite is precursor used for the synthesis of various organophosphorus compounds. used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.

Uses

Diethyl phosphite (DEPI) is a versatile reactive intermediate used in the production of various phosphorus based substances. It may be used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.
It may be used:

1. in the stereoselective synthesis of β-fluorinated alkylphosphonates
2. Used in synthesis of homoallylic bromide
3. Used in synthesis of series of carbazole-based α-aminophosphonates
4. used as an extraction agent and phosphate intermediate.
5. Used in synthesis of pesticides kitazine and phosethyl-Al as well as synthetic O, O-diethyl phosphoryl chloride.
6. used for the synthesis of plasticizers, flame retardants, etc.
7. Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Definition

ChEBI: A phosphonic ester that is the diethyl ester of phosphonic acid.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 3327, 1988 DOI: 10.1016/0040-4039(88)85153-0

Synthesis Reference(s)

Synthetic Communications, 18, p. 665, 1988 DOI: 10.1080/00397918808077352

General Description

Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.