(R)-(+)-TolBINAP

Reaction

1. Useful ligand for palladium-catalyzed carbon-oxygen bond formation.
2. Ligand for palladium-catalyzed α-arylation of ketones.
3. Ligand for Cu-catalyzed asymmetric conjugate reduction.
4. Ligand for Cu-catalyzed asymmetric dienolate addition to aldehydes.
5. Enantioselective conjugate reduction of lactones and lactams.
6. Ligand used in the enantioselective cycloaddition of allenylsilanes with α-Imino esters.
7. Catalytic Aldol reaction to ketones.
8. Ligand with rhodium catalyses [2+2+2] cycloaddition reaction of alkenes and alkynes.
9. Ligand used in the copper-catalyzed asymmetric conjugate addition of alkyl Grignard reagents on α,β-unsaturated esters.
10. Ligand used in the copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate addition and intramolecular enolate trapping. 

Chemical Properties

White to cream powder

Uses

(R)-T-BINAP complexes derived from rhodium precursors are used for the asymmetric hydroformylation of vinyl acetate. It may be employed as chiral catalyst for allylation of N-tosyl α-imino esters.

Uses

(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl is used as chiral catalyst ligand. (R)-T-BINAP complexes derived from rhodium precursors are used for the asymmetric hydroformylation of vinyl acetate. It is a catalysts used for reductive amination of ketones, Pt dications for cation trapping, Rh(I)-catalyst for hydrogenation of acetamidoacrylic acid derivatives.

General Description

BINAP is based on a bis naphthalene backbone with different phosphine derivatives. 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl (p-Tol-BINAP)·AgF complex catalyzed asymmetric Mukaiyama-type aldol reaction is reported.