Ethyl isonicotinate

clear colorless to light brown liquid

Ethyl isonicotinate is an organic building block, used in the synthesis of various pharmaceutical and biologically active compounds. It is also a pyridine compound that is shown to be able to trap the thrips in the corp.

Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx.

In a 250 mL three-necked flask was added isonicotinic acid 4. 9 g ( 0.04 mo l), anhydrous ethanol 40 mL, the corresponding amount of concentrated H2SO4, phase transfer catalyst; respectively, a stirrer and a distillation device were installed. Heated with stirring, gradually increased the temperature, evaporated ethanol to the required liquid temperature, stopped heating, natural cooling, poured out at about 50 C. The reactants were white solid at room temperature. With saturated Na2CO3 aqueous solution to neutralize the product to pH about 7 (such as the volume is too large can be added to part of the solid Na2CO3 ), to 20 mL of chloroform extraction, the combined organic layer was transferred to the decompression distillation flask, the first recovery of chloroform at atmospheric pressure and then decompression distillation of ethyl isonicotinate at 1. 06 k Pa to collect the 92 ~ & nbsp; 95 C fractions, weighed, calculated yield. The product was a slightly yellow liquid (colorless after refining), bp 92 ~ 95 C /1. 06 k Pa, n20D = 1. 5005; Infrared spectrum: IR (cm- 1 ) 1733 ( C= O) 1283 ( C- O- C), purity is 99%.