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Isonicotinic acid

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Isonicotinic acid Basic information
Isonicotinic acid Chemical Properties
  • Melting point:≥300 °C (lit.)
  • Boiling point:260 °C (15 mmHg)
  • Density 1,47g/cm
  • refractive index 1.5423 (estimate)
  • Flash point:260°C/15mm
  • storage temp. no restrictions.
  • solubility 6g/l
  • pka4.96(at 25℃)
  • form powder
  • color yellow to tan
  • PH3-4 (6g/l, H2O, 20℃)(saturated solution)
  • Water Solubility 5.2 g/L (20 ºC)
  • Merck 14,5187
  • BRN 109599
  • InChIKeyTWBYWOBDOCUKOW-UHFFFAOYSA-N
  • CAS DataBase Reference55-22-1(CAS DataBase Reference)
  • NIST Chemistry ReferenceIsonicotinic acid(55-22-1)
  • EPA Substance Registry SystemIsonicotinic acid (55-22-1)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 2
  • RTECS NS1103000
  • TSCA Yes
  • HS Code 29333999
  • ToxicityLD50 orally in Rabbit: 5000 mg/kg
MSDS
Isonicotinic acid Usage And Synthesis
  • Chemical Propertieswhite to light yellow crystal powder
  • UsesIsonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) .
    Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid.
    Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals.
    Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines
  • DefinitionChEBI: A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring.
  • Purification MethodsCrystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]
Isonicotinic acid Preparation Products And Raw materials
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