钩吻素子 性质
| 熔点 | 168℃ |
|---|---|
| 沸点 | 436.5±45.0 °C(Predicted) |
| 密度 | 1.42 |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：31.25 mg/mL（101.99 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.67±0.40(Predicted) |
| 颜色 | 黄褐色 |
| 旋光度 (Optical Rotation) | [α]/D 295 to 245° |
| InChI | InChI=1/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/s3 |
| InChIKey | VTLYEMHGPMGUOT-KWZROIJWNA-N |
| SMILES | C1C=CC2N=C3[C@]4([H])OC[C@@]5([H])[C@]([H])([C@]6(C=C)CN(C)[C@]5(C[C@@]36C=2C=1)[H])C4 |&1:6,10,12,14,20,22,r| |
钩吻素子 用途与合成方法
Koumine (0.5, 1 and 2 mg/mL) dose- and time-dependently inhibits the proliferation of MCF-7 cells, with an IC
50
of 124 µg/mL at 72 h. Koumine induces apoptosis, causes cell cycle arrest at G2/M phase.
Koumine (0.5, 1 and 2 mg/mL) up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in a dose-dependent manner in MCF-7 Cells.
Koumine (25, 50, 100, and 200 μM) decreases the protein and mRNA levels of microglia M1 polarization factors in LPS-induced BV2 cells.
Koumine is less toxic, with the median lethal dose (LD
50
) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA).
Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg.
Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level.
药理药效:对精神神经、呼吸及心血管系统有一定的刺激兴奋作用，具有用于治疗神经病理性疼痛的潜在价值。
钩吻素子 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-N1440 | 钩吻素子 | 1358-76-5 | 5mg | 600 |
| 2025-12-22 | HY-N1440 | 钩吻素子 | 1358-76-5 | 10mM * 1mLin DMSO | 660 |
