茯苓酸
茯苓酸 性质
| 熔点 | 300 °C(Solv: methanol (67-56-1); acetone (67-64-1)) |
|---|---|
| 沸点 | 612.2±55.0 °C(Predicted) |
| 密度 | 1.10±0.1 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 甲醇（微量）、吡啶（微量） |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.65±0.10(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
茯苓酸 用途与合成方法
闪点：184.7ºC
密度： 1.1 g/cm3
沸点：612.2ºC at 760 mmHg
折射率：1.539
蒸汽压：1.51E-17mmHg at 25°C 茯苓酸是中药茯苓的特有成分,也是茯苓的主要活性成分之一,具有多种与药效有关的药理活性.目前茯苓酸已经引起广泛关注,对其研究越来越多,茯苓酸在抗肿瘤、抗炎、抗氧化、降血糖、镇静催眠等方面应用广泛。 http://www.chemsrc.com/cas/54239-37-1_671704.html Pachymic acid 是一种来自 P. cocos 的三萜类化合物。Pachymic acid 抑制 Akt 和 ERK 信号传导途径。
|
Akt
|
ERK
|
Pachymic acid (PA) is able to inhibit gallbladder cancer tumorigenesis involving affection of Akt and ERK signaling pathways. Pachymic acid (PA) treatment significantly inhibits Rho A, Akt and ERK pathway in gallbladder carcinoma cells. Pachymic acid (PA) treatment can dose-dependently downregulate PCNA, ICAM-1, RhoA, p-Akt and pERK. Cell growth is inhibited by 10 µg/mL Pachymic acid (PA) 12 h after treatment, and a concentration of 30 µg/mL further reduced cell growth. The growth of cells is suppressed in a time- and dose-dependent manner. After 48 h treatment, about 25%, 40% and 70% of the cell growth are inhibited by Pachymic acid (PA) at concentration of 10 µg/mL, 20 µg/mL and 30 µg/mL, respectively. Pachymic acid (PA) also inhibits the growth of gallbladder carcinoma cells in a time-dependent and dose-dependent manner.
To evaluate the anti-tumor activity of Pachymic acid (PA) in vivo, human lung cancer NCI-H23 tumor xenograft models are used. Pachymic acid (PA) significantly suppresses tumor growth at doses of 30 and 60 mg/kg for 21 days compared with the control group.
药理药效:对肝脏具细胞毒作用，能竞争性抑制磷脂酶A2（phospholipase A2，PLA2）的生物活性，降低PLA2介导的细胞损伤。
茯苓酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0371 | 1 mg | 720 | ||
| 2024-11-08 | HY-N0371 | 茯苓酸 | 29070-92-6 | 5mg | 1800 |
