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Basic information Chemical Properties Uses Safety Related Supplier
4-Pyridinecarboxaldehyde Basic information
4-Pyridinecarboxaldehyde Chemical Properties
  • Melting point:-4--2°C
  • Boiling point:71-73 °C10 mm Hg(lit.)
  • Density 1.137 g/mL at 20 °C(lit.)
  • vapor pressure 0.02 hPa (20 °C)
  • refractive index n20/D 1.544(lit.)
  • Flash point:130 °F
  • storage temp. 2-8°C
  • solubility 20g/l
  • pka12.05(at 30℃)
  • form liquid (clear)
  • color clear brown-yellow
  • PH7-8 (H2O, 20℃)(saturated aqueous solution)
  • Water Solubility 20 g/L (20 ºC)
  • Sensitive Air Sensitive
  • BRN 105342
  • CAS DataBase Reference872-85-5(CAS DataBase Reference)
  • NIST Chemistry Reference4-Pyridinecarboxaldehyde(872-85-5)
  • EPA Substance Registry System4-Pyridinecarboxaldehyde (872-85-5)
Safety Information
  • Hazard Codes Xi,F
  • Risk Statements 36/37/38-10
  • Safety Statements 26-36-36/37/39-16
  • RIDADR UN 1989
  • WGK Germany 1
  • RTECS NR9400000
  • 8-10-23
  • Hazard Note Irritant/Keep Cold/Air Sensitive
  • TSCA Yes
  • HazardClass 3.2
  • PackingGroup III
  • HS Code 29333999
  • ToxicityLD50 orally in Rabbit: 2355 mg/kg LD50 dermal Rat > 2000 mg/kg
4-Pyridinecarboxaldehyde Usage And Synthesis
  • Chemical Properties

    4-Pyridinecarboxaldehyde(4PCA) is a slightly yellow oily liquid. Its relative density is 1.122, and its refractive index is 1.5352 (25°C). Flash point is 54 ° C. 4-Pyridinecarboxaldehyde is soluble in water and ether.4-Pyridinecarboxaldehyde, also commonly called pyridine-2-carboxaldehyde, is an organic compound with the formula NC5H4CHO. 4-Pyridinecarboxaldehyde is a colorless oily liquid with a distinctive odor. Older samples are often brown-colored owing to impurities.

  • Uses

    4-Pyridinecarboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.4-Pyridinecarboxaldehyde and some of its derivatives have also been reported as useful transamination reagents to introduce ketone or aldehyde groups onto the N-termini of antibodies for subsequent site-specifically conjugate aminooxy-functionalized molecules (including fluorescent dyes, polyethylene glycol, or porphyrins) to these entities.
    4-Pyridinecarboxaldehyde can be used for the synthesis of: β-Unsaturated amides by coupling with N,N-disubstituted formamides; meso-Substituted A3-corroles; N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs); 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents; 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.

  • Chemical Propertiesclear yellow-brown liquid
  • Purification MethodsPurified as for pyridine-2-aldehyde. [Beilstein 21 III/IV 2529, 21/7 V 351.]
4-Pyridinecarboxaldehyde Preparation Products And Raw materials
4-Pyridinecarboxaldehyde(872-85-5)Related Product Information
  • Company Name:Alfa Aesar Gold
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  • Company Name:Nantong Xiaochang Pharmaceutical Trading Co., Ltd. Gold
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  • Company Name:Wuhan yuqing jiaheng pharmaceutical co. LTD Gold
  • Tel:15827508403
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