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Verbascoside Basic information
Verbascoside Chemical Properties
  • Melting point:232℃
  • Boiling point:908.8±65.0 °C(Predicted)
  • Density 1.60±0.1 g/cm3(Predicted)
  • storage temp. room temp
  • pka9.31±0.10(Predicted)
  • CAS DataBase Reference61276-17-3(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 2
  • RTECS LZ5786000
  • HS Code 29389090
  • ToxicityLD50 oral in rat: > 5gm/kg
Verbascoside Usage And Synthesis
  • Chemical PropertiesWhite solid
  • Enzyme inhibitorThis plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
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