Basic information Description Natural occurrences Mechanism of action Safety Related Supplier
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Verbascoside

Basic information Description Natural occurrences Mechanism of action Safety Related Supplier
Verbascoside Basic information
Verbascoside Chemical Properties
  • Melting point:232℃
  • Boiling point:908.8±65.0 °C(Predicted)
  • Density 1.60±0.1 g/cm3(Predicted)
  • storage temp. room temp
  • pka9.31±0.10(Predicted)
  • InChIKeyFBSKJMQYURKNSU-ZLSOWSIRSA-N
  • CAS DataBase Reference61276-17-3(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 2
  • RTECS LZ5786000
  • HS Code 29389090
  • ToxicityLD50 oral in rat: > 5gm/kg
Verbascoside Usage And Synthesis
  • Description

    Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

  • Natural occurrences

    Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

  • Mechanism of action

    It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

  • Chemical PropertiesWhite solid
  • Enzyme inhibitorThis plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
Verbascoside(61276-17-3)Related Product Information
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