Description Natural occurrences Mechanism of action
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Verbascoside

Description Natural occurrences Mechanism of action
Verbascoside Structure
Verbascoside
  • CAS No.61276-17-3
  • Chemical Name:Verbascoside
  • CBNumber:CB2306760
  • Molecular Formula:C29H36O15
  • Formula Weight:624.59
  • MOL File:61276-17-3.mol
Verbascoside Property
  • Melting point: :232℃
  • Boiling point: :908.8±65.0 °C(Predicted)
  • Density  :1.60±0.1 g/cm3(Predicted)
  • storage temp.  :room temp
  • pka :9.31±0.10(Predicted)
  • InChIKey :FBSKJMQYURKNSU-ZLSOWSIRSA-N
  • CAS DataBase Reference :61276-17-3(CAS DataBase Reference)
  • FDA UNII :3TGX09BD5B
Safety
  • Safety Statements  :24/25
  • WGK Germany  :2
  • RTECS  :LZ5786000
  • HS Code  :29389090
  • Toxicity :LD50 oral in rat: > 5gm/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Verbascoside Price More Price(9)
  • Brand: Sigma-Aldrich
  • Product number: 00820580
  • Product name : Verbascoside
  • Purity: primary pharmaceutical reference standard
  • Packaging: 10mg
  • Price: $338
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1711455
  • Product name : Verbascoside
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 15mg
  • Price: $416
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: V0153
  • Product name : Verbascoside
  • Purity: >97.0%(HPLC)
  • Packaging: 10mg
  • Price: $237
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: V0153
  • Product name : Verbascoside
  • Purity: >97.0%(HPLC)
  • Packaging: 50mg
  • Price: $711
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24965
  • Product name : Verbascoside
  • Purity:  ≥98%
  • Packaging: 1mg
  • Price: $35
  • Updated: 2020/06/24
  • Buy: Buy

Verbascoside Chemical Properties,Usage,Production

  • Description

    Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

  • Natural occurrences

    Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

  • Mechanism of action

    It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

  • Chemical Properties White solid
  • Enzyme inhibitor This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
Verbascoside Preparation Products And Raw materials
Raw materials
Preparation Products
Global(203)Suppliers
  • Supplier:
    Henan Tianfu Chemical Co.,Ltd.
  • Tel:0371-55170693
  • Fax:0371-55170693
  • Email:info@tianfuchem.com
  • Country:CHINA
  • ProdList:22623
  • Advantage:55
  • Supplier:
    Haihang Industry Co.,Ltd
  • Tel:86-531-88032799
  • Fax:+86 531 8582 1093
  • Email:export@haihangchem.com
  • Country:CHINA
  • ProdList:10546
  • Advantage:58
  • Supplier:
    Xi'an Kono chem co., Ltd.,
  • Tel:18292830413 029-86107037-8014
  • Fax:
  • Email:sales7@konochemical.com
  • Country:CHINA
  • ProdList:3000
  • Advantage:58
61276-17-3, VerbascosideRelated Search:
  • glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos
  • ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,
  • Acetoside
  • Extract from Verbena minutiflora (B864379)
  • [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • VERBASCOSIDE WITH HPLC
  • 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate]
  • 3,4-Dihydroxyphenethyl alcohol acteoside
  • Verbacoside
  • Acteoside(Verbascoside)
  • Distinctive PhytosteM Lilac
  • Verbascoside ,98%
  • NSC 603831
  • Russetinol
  • StereosperMin
  • TJC 160
  • Verbascoside(Acteoside)
  • Verbascoside, froM Cistanche deserticola Y.C.Ma
  • VERBASCOSIDE
  • ISOVERBASCOSIDE
  • KUSAGININ
  • B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-
  • 4-(3-(3,4-dihydroxyphenyl)-2-propenoate),(e)-beta-d-yl)
  • Verbascoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • ACTEOSIDE
  • β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
  • Nano Liposomal Acteoside
  • Verbascoside, 98%, from Cistanche deserticola Y.C.Ma
  • Acteoside Kusaginin 61276-17-3
  • Kusagi
  • Acteoside Standard
  • 61276-17-3
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Miscellaneous Natural Products