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Basic information Description References Safety Related Supplier
Guaifenesin Basic information
Guaifenesin Chemical Properties
  • Melting point:77-81 °C
  • Boiling point:215 °C (19 mmHg)
  • Density 1.1825 (rough estimate)
  • refractive index 1.5550 (estimate)
  • Flash point:215°C/19mm
  • storage temp. Refrigerator
  • solubility 50g/l (experimental)
  • form neat
  • Water Solubility 5 g/100 mL (25 ºC)
  • Merck 14,4555
  • BRN 2049375
  • CAS DataBase Reference93-14-1(CAS DataBase Reference)
  • NIST Chemistry Reference3-(O-methoxyphenoxy)-1,2-propanediol(93-14-1)
  • EPA Substance Registry SystemGuaifenesin (93-14-1)
Safety Information
Guaifenesin Usage And Synthesis
  • DescriptionGuaifenesin is an oral expectorant drug. The expectorant action of guaifenesin is mediated by stimulation of the gastrointestinal tract. It is a common ingredient in prescription and over-the-counter medications used to treat cough due to colds and minor upper respiratory infections.
  • References[1] Peter V. Dicpinigaitis and Yvonne E. Gayle, Effect of Guaifenesin on Cough Reflex Sensitivity, 2003, vol. 124, 2178-2181
    [2] Leonid Kagan, Eran Lavy and Ammon Hoffmann, Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model, Pulmonary Pharmacology & Therapeutics, 2009, vol. 22, 260-265
  • Chemical PropertiesWhite Solid
  • UsesCentrally acting muscle relaxant with expectorant properties
  • UsesUsed to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
  • brand nameMucinex (Adams).
  • Veterinary Drugs and TreatmentsIn veterinary medicine, guaifenesin is used to induce muscle relaxation and restraint as an adjunct to anesthesia for short procedures (30 – 60 minutes) in large and small animal species. There are combination oral products containing guaifenesin for treating respiratory conditions in horses.
    In human medicine, guaifenesin has long been touted as an oral expectorant, but definitive proof of its efficacy is lacking.
Guaifenesin Preparation Products And Raw materials
Guaifenesin(93-14-1)Related Product Information
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