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Guaiacol Structure


Chemical Properties

Melting point 26-29 °C (lit.)
Boiling point 205 °C (lit.)
Density  1.129 g/mL at 25 °C (lit.)
vapor density  4.27 (vs air)
vapor pressure  0.11 mm Hg ( 25 °C)
refractive index  n20/D 1.543(lit.)
Flash point 180 °F
storage temp.  2-8°C
solubility  H2O: insoluble
form  Liquid After Melting
pka 9.98(at 25℃)
color  Clear colorless to light yellow
PH 5.4 (10g/l, H2O, 20℃)
Odor at 1.00 % in dipropylene glycol. phenolic smoke spice vanilla woody
Odor Type phenolic
Odor Threshold 0.0074ppm
Water Solubility  17 g/L (15 ºC)
FreezingPoint  28℃
Sensitive  Air Sensitive
JECFA Number 713
Merck  14,4553
BRN  508112
Dielectric constant 11.0(-18℃)
Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
LogP 1.34
CAS DataBase Reference 90-05-1(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System Guaiacol (90-05-1)

Safety Information

Hazard Codes  Xn,T,Xi
Risk Statements  22-36/38
Safety Statements  26
RIDADR  2810
WGK Germany  1
RTECS  SL7525000
Autoignition Temperature 750 °C
Hazard Note  Toxic/Irritant
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Hazardous Substances Data 90-05-1(Hazardous Substances Data)
Toxicity LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.
Toxicity LD50 orally in rats: 725 mg/kg (Taylor)


Usage And Synthesis

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